Title

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.

Document Type

Article

Publication Date

1-2018

JAX Location

Reprint Collection

JAX Source

J Infect Dis 2018 Jan; 217(1):58-63

PMID

29087482

DOI

https://doi.org/10.1093/infdis/jix562

Abstract

Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage and disease were observed exclusively in EBOV-infected mice. These abnormalities were associated with significantly higher EBOV replication in the liver but not in the spleen, suggesting that in this model, efficiency of viral replication in select tissues early in infection may contribute to differences in viral pathogenicity. J Infect Dis 2018 Jan; 217(1):58-63.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS