Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.
Document Type
Article
Publication Date
9-2018
JAX Source
Biomaterials 2018 Sep; 178:527-545
Volume
178
First Page
527
Last Page
545
ISSN
1878-5905
PMID
29657091
DOI
https://doi.org/10.1016/j.biomaterials.2018.03.057
Abstract
Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease. Here, we developed injectable diblock copolypeptide hydrogels (DCH) for NSPC transplantation that contain hydrophilic segments of modified l-methionine (Met). Multiple Met-based DCH were fabricated by post-polymerization modification of Met to various functional derivatives, and incorporation of different amino acid comonomers into hydrophilic segments. Met-based DCH assembled into self-healing hydrogels with concentration and composition dependent mechanical properties. Mechanical properties of non-ionic Met-sulfoxide formulations (DCH
Recommended Citation
Wollenberg A,
O'Shea T,
Kim J,
Czechanski A,
Reinholdt L,
Sofroniew M,
Deming T.
Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. Biomaterials 2018 Sep; 178:527-545