Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.
Biomaterials 2018 Sep; 178:527-545
Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease. Here, we developed injectable diblock copolypeptide hydrogels (DCH) for NSPC transplantation that contain hydrophilic segments of modified l-methionine (Met). Multiple Met-based DCH were fabricated by post-polymerization modification of Met to various functional derivatives, and incorporation of different amino acid comonomers into hydrophilic segments. Met-based DCH assembled into self-healing hydrogels with concentration and composition dependent mechanical properties. Mechanical properties of non-ionic Met-sulfoxide formulations (DCH
Wollenberg, A L; O'Shea, T M; Kim, J H; Czechanski, Anne M; Reinholdt, Laura G; Sofroniew, M V; and Deming, T J, "Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery." (2018). Faculty Research 2018. 159.