Title

Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.

Document Type

Article

Publication Date

9-2018

JAX Source

Biomaterials 2018 Sep; 178:527-545

PMID

29657091

DOI

https://doi.org/10.1016/j.biomaterials.2018.03.057

Abstract

Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease. Here, we developed injectable diblock copolypeptide hydrogels (DCH) for NSPC transplantation that contain hydrophilic segments of modified l-methionine (Met). Multiple Met-based DCH were fabricated by post-polymerization modification of Met to various functional derivatives, and incorporation of different amino acid comonomers into hydrophilic segments. Met-based DCH assembled into self-healing hydrogels with concentration and composition dependent mechanical properties. Mechanical properties of non-ionic Met-sulfoxide formulations (DCH

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