Title

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults.

Document Type

Article

Publication Date

8-2018

JAX Source

Neurol Clin 2018 Aug; 36(3):421-437

PMID

30072063

DOI

https://doi.org/10.1016/j.ncl.2018.04.002

Grant

CA190121

Abstract

Recent advances in molecular analysis and genome sequencing have prompted a paradigm shift in neuropathology. This article discusses the discovery and clinical relevance of molecular biomarkers in diffuse gliomas in adults and how these biomarkers led to revision of the World Health Organization classification of these tumors. We relate progress in clinical classification to an overview of studies using molecular profiling to study gene expression and DNA methylation to categorize diffuse gliomas in adults and issues dealing with intratumoral heterogeneity. These efforts will refine the taxonomy of diffuse gliomas, facilitate selection of appropriate treatment regimens, and ultimately improve patient's lives.

Comments

The authors thank members of the Verhaak laboratory for insightful discussion and valuable input. The authors thank Zoe¨ Reifsnyder of the Jackson Laboratory creative team for artwork.

Please contact the Joan Staats Library for information regarding this document.

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