Document Type

Article

Publication Date

9-25-2018

JAX Source

Sci Rep 2018 Sep 25; 8(1):14339

PMID

30254279

DOI

https://doi.org/10.1038/s41598-018-32579-9

Grant

EY019943,CA34196

Abstract

The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revealed that these animals exhibit early visual system abnormalities and are depleted of RHODOPSIN prior to pronounced photoreceptor death. A KO of AdipoR1 post-development either in photoreceptors or the retinal pigment epithelium (RPE) resulted in decreased expression of retinal proteins, establishing a role for ADIPOR1 in supporting vision in adulthood. Subsequent analysis of the Mfrp

Comments

This open access article is licensed under a Creative Commons Attribution 4.0 International License

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