Document Type
Article
Publication Date
2-6-2018
JAX Source
Cell Rep 2018 Feb 6; 22(6):1392-1400
PMID
29425496
DOI
https://doi.org/10.1016/j.celrep.2018.01.035
Abstract
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy. Cell Rep 2018 Feb 6; 22(6):1392-1400
Recommended Citation
Munshi, Mansa A; Gardin, Justin M; Singh, Ashutosh; Luberto, Chiara; Rieger, Robert; Bouklas, Tejas; Fries, Bettina C; and Del Poeta, Maurizio, "The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans." (2018). Faculty Research 2018. 36.
https://mouseion.jax.org/stfb2018/36
Comments
Open access Under a Creative Commons license.