Document Type

Article

Publication Date

2-6-2018

JAX Source

Cell Rep 2018 Feb 6; 22(6):1392-1400

PMID

29425496

DOI

https://doi.org/10.1016/j.celrep.2018.01.035

Abstract

Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy. Cell Rep 2018 Feb 6; 22(6):1392-1400

Comments

Open access Under a Creative Commons license.

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