JACC Basic Transl Sci
JACC Basic Transl Sci 2021 Apr; 6(4):331-345
There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate that cardiomyocyte severe acute respiratory syndrome coronavirus 2 infection results in contractile deficits, cytokine production, sarcomere disassembly, and cell death. These findings implicate direct infection of cardiomyocytes in the pathogenesis of COVID-19 myocardial pathology and provides a model system to study this emerging disease.
Bailey, Adam L; Dmytrenko, Oleksandr; Greenberg, Lina; Bredemeyer, Andrea L; Ma, Pan; Liu, Jing; Penna, Vinay; Winkler, Emma S; Sviben, Sanja; Brooks, Erin; Nair, Ajith P; Heck, Kent A; Rali, Aniket S; Simpson, Leo; Saririan, Mehrdad; Hobohm, Dan; Stump, W Tom; Fitzpatrick, James A; Xie, Xuping; Zhang, Xianwen; Shi, Pei-Yong; Hinson, J Travis; Gi, Weng-Tein; Schmidt, Constanze; Leuschner, Florian; Lin, Chieh-Yu; Diamond, Michael S; Greenberg, Michael J; and Lavine, Kory J, "SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis." (2021). Faculty Research 2021. 109.