Document Type

Article

Publication Date

3-9-2021

Publication Title

Elife

Keywords

JMG

JAX Source

Elife 2021 Mar 9; 10:e62585

Volume

10

ISSN

2050-084X

PMID

33687326

DOI

https://doi.org/10.7554/elife.62585

Grant

AG038070

Abstract

Little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand these changes, we measured mRNA and protein levels in genetically diverse mice at different ages. We observed distinctive change in mRNA and protein levels as a function of age. Changes in both mRNA and protein are associated with increased immune infiltration and decreases in mitochondrial function. Proteins show a greater extent of change and reveal changes in a wide array of biological processes including unique, organ-specific features of aging in kidney. Most importantly, we observed functionally important age-related changes in protein that occur in the absence of corresponding changes in mRNA. Our findings suggest that mRNA profiling alone provides an incomplete picture of molecular aging in the kidney and that examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.

Comments

We gratefully acknowledge the contribution of Heidi Munger and the Genome Technologies Service at The Jackson Laboratory for expert assistance with the work described in this publication.

This article is distributed under the terms of the Creative Commons Attribution License.

Download

Share

COinS