Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS.
Document Type
Article
Publication Date
7-5-2021
Publication Title
The Journal of experimental medicine
Keywords
JMG
JAX Source
J Exp Med 2021 Jul 5; 218(7):e20201544
Volume
218
Issue
7
ISSN
1540-9538
PMID
34129017
DOI
https://doi.org/10.1084/jem.20201544
Abstract
With a growing aged population, there is an imminent need to develop new therapeutic strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis and myelodysplastic syndrome (MDS). Cell-intrinsic dysregulation of innate immune- and inflammatory-related pathways as well as systemic inflammation have been implicated in hematopoietic defects associated with aging, clonal hematopoiesis, and MDS. Here, we review and discuss the role of dysregulated innate immune and inflammatory signaling that contribute to the competitive advantage and clonal dominance of preleukemic and MDS-derived hematopoietic cells. We also propose how emerging concepts will further reveal critical biology and novel therapeutic opportunities.
Recommended Citation
Trowbridge JJ,
Starczynowski D.
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS. J Exp Med 2021 Jul 5; 218(7):e20201544
Comments
We thank members of the Trowbridge and Starczynowski laboratories for helpful suggestions and editing of the review.