Title

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS.

Document Type

Article

Publication Date

7-5-2021

Publication Title

The Journal of experimental medicine

Keywords

JMG

JAX Source

J Exp Med 2021 Jul 5; 218(7):e20201544

Volume

218

Issue

7

ISSN

1540-9538

PMID

34129017

DOI

https://doi.org/10.1084/jem.20201544

Abstract

With a growing aged population, there is an imminent need to develop new therapeutic strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis and myelodysplastic syndrome (MDS). Cell-intrinsic dysregulation of innate immune- and inflammatory-related pathways as well as systemic inflammation have been implicated in hematopoietic defects associated with aging, clonal hematopoiesis, and MDS. Here, we review and discuss the role of dysregulated innate immune and inflammatory signaling that contribute to the competitive advantage and clonal dominance of preleukemic and MDS-derived hematopoietic cells. We also propose how emerging concepts will further reveal critical biology and novel therapeutic opportunities.

Comments

We thank members of the Trowbridge and Starczynowski laboratories for helpful suggestions and editing of the review.

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