Document Type

Article

Publication Date

1-1-2021

Publication Title

Front Neurosci

Keywords

JGM, JMG

JAX Source

Front Neurosci 2021 Aug 31; 15:725500

Volume

15

First Page

725500

Last Page

725500

ISSN

1662-4548

PMID

34531718

DOI

https://doi.org/10.3389/fnins.2021.725500

Grant

AA027858, DA043809

Abstract

Substance use disorders (SUDs) remain a significant public health challenge, affecting tens of millions of individuals worldwide each year. Often comorbid with other psychiatric disorders, SUD can be poly-drug and involve several different substances including cocaine, opiates, nicotine, and alcohol. SUD has a strong genetic component. Much of SUD research has focused on the neurologic and genetic facets of consumption behavior. There is now interest in the role of the gut microbiome in the pathogenesis of SUD. In this review, we summarize current animal and clinical evidence that the gut microbiome is involved in SUD, then address the underlying mechanisms by which the gut microbiome interacts with SUD through metabolomic, immune, neurological, and epigenetic mechanisms. Lastly, we discuss methods using various inbred and outbred mice models to gain an integrative understanding of the microbiome and host genetic controls in SUD.

Comments

This is an open-access article distributed under the terms of the Creative Commons Attribution License.

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