Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors

Authors

Tamara J Phillips
Tyler A. Roy, The Jackson LaboratoryFollow
Sara J Aldrich
Harue Baba
Jason Erk
John R K Mootz
Cheryl Reed
Elissa J Chesler, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

8-26-2021

Publication Title

Front Psychiatry

JAX Source

Front Psychiatry 2021 Aug 26; 12:725839

Volume

12

First Page

725839

Last Page

725839

ISSN

1664-0640

PMID

34512422

DOI

https://doi.org/10.3389/fpsyt.2021.725839

Grant

DA039841

Abstract

Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention. Methamphetamine effects on dopamine re-uptake and efflux are associated with its addiction potential. However, methamphetamine also serves as a substrate for the trace amine-associated receptor 1 (TAAR1). Growing evidence in animal models indicates that increasing TAAR1 function reduces drug self-administration and intake. We previously determined that a non-synonymous single nucleotide polymorphism (SNP) in

Comments

The authors gratefully acknowledge the assistance of the Scientific Services at The Jackson Laboratory, in particular Genetic Engineering Technology service.

This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Recommended Citation

Phillips T, Roy TA, Aldrich S, Baba H, Erk J, Mootz J, Reed C, Chesler E. Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors Front Psychiatry 2021 Aug 26; 12:725839