Front Psychiatry 2021 Aug 26; 12:725839
Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention. Methamphetamine effects on dopamine re-uptake and efflux are associated with its addiction potential. However, methamphetamine also serves as a substrate for the trace amine-associated receptor 1 (TAAR1). Growing evidence in animal models indicates that increasing TAAR1 function reduces drug self-administration and intake. We previously determined that a non-synonymous single nucleotide polymorphism (SNP) in
Phillips, Tamara J; Roy, Tyler A.; Aldrich, Sara J; Baba, Harue; Erk, Jason; Mootz, John R K; Reed, Cheryl; and Chesler, Elissa J, "Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors" (2021). Faculty Research 2021. 192.