Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer.
Document Type
Article
Publication Date
9-14-2021
Publication Title
Transl Oncol
Keywords
JMG
JAX Source
Transl Oncol 2021 Sep 14; 14(12):101217
Volume
14
Issue
12
First Page
101217
Last Page
101217
ISSN
1936-5233
PMID
34530192
DOI
https://doi.org/10.1016/j.tranon.2021.101217
Abstract
Epithelial ovarian cancer (EOC) is an immunologically active malignancy, but thus far immune therapy has had limited success in clinical trials. One barrier to implementation of efficacious immune therapies is a lack of knowledge of the effect of chemotherapy on the monocyte-derived component of the immune infiltrate within the tumor. We utilized the ID8 murine EOC model to investigate alterations within tumor ascites that occur following administration of platinum chemotherapy. Cisplatin treatment resulted in a significant increase in monocytes within the ascites of tumor bearing mice. We identified that CD11b
Recommended Citation
Hopkins D,
Sanchez H,
Berwin B,
Wilkinson-Ryan I.
Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer. Transl Oncol 2021 Sep 14; 14(12):101217