Title

Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer.

Document Type

Article

Publication Date

9-14-2021

Publication Title

Transl Oncol

Keywords

JMG

JAX Source

Transl Oncol 2021 Sep 14; 14(12):101217

Volume

14

Issue

12

First Page

101217

Last Page

101217

ISSN

1936-5233

PMID

34530192

DOI

https://doi.org/10.1016/j.tranon.2021.101217

Abstract

Epithelial ovarian cancer (EOC) is an immunologically active malignancy, but thus far immune therapy has had limited success in clinical trials. One barrier to implementation of efficacious immune therapies is a lack of knowledge of the effect of chemotherapy on the monocyte-derived component of the immune infiltrate within the tumor. We utilized the ID8 murine EOC model to investigate alterations within tumor ascites that occur following administration of platinum chemotherapy. Cisplatin treatment resulted in a significant increase in monocytes within the ascites of tumor bearing mice. We identified that CD11b

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