Title

Targeting T cell metabolism for immunotherapy.

Document Type

Article

Publication Date

12-2021

Publication Title

Journal of leukocyte biology

Keywords

JMG

JAX Source

J Leukoc Biol 2021 Dec; 110(6):1081-1090

Volume

110

Issue

6

First Page

1081

Last Page

1090

ISSN

1938-3673

PMID

34779530

DOI

https://doi.org/10.1002/jlb.5mr0921-011r

Grant

CA034196

Abstract

T cells play an important role in antitumor immunity. Numbers and function of T cells are controlled by regulating the uptake and utilization of nutrients, and their antitumor activity can be promoted by targeting metabolic pathways. In this review, we highlight the relationship between metabolism and cellular function of T cells. Specifically, we emphasize the metabolic state of tumor-infiltrating T cells and review key pathways that affect the antitumor function of T cells. In the field of tumor immunotherapy, targeting T cell metabolism to enhance the immune response is a new therapeutic strategy for enhancing immunotherapy combined with traditional treatments.

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