The exploration of pluripotency space: Charting cell state transitions in peri-implantation development.

Document Type

Article

Publication Date

11-4-2021

Publication Title

Cell Stem Cell

Keywords

JMG, Animals, Cell Differentiation, Embryo Implantation, Embryo, Mammalian, Germ Layers, Humans, Mice, Pluripotent Stem Cells

JAX Source

Cell Stem Cell 2021 Nov 4; 28(11):1896-1906

Volume

28

Issue

11

First Page

1896

Last Page

1906

ISSN

1875-9777

PMID

34672948

DOI

https://doi.org/10.1016/j.stem.2021.10.001

Abstract

Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developmental potential as they progress from pre-implantation through post-implantation stages of development. Recent studies of cultured mouse and human pluripotent stem cells (hPSCs) have identified cells representative of an intermediate stage (referred to as the formative state) between naive pluripotency (equivalent to pre-implantation epiblast) and primed pluripotency (equivalent to late post-implantation epiblast). We examine these recent findings in light of our knowledge of peri-implantation mouse and human development, and we consider the implications of this work for deriving human embryo models from pluripotent cells.

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