The exploration of pluripotency space: Charting cell state transitions in peri-implantation development.
Cell Stem Cell
JMG, Animals, Cell Differentiation, Embryo Implantation, Embryo, Mammalian, Germ Layers, Humans, Mice, Pluripotent Stem Cells
Cell Stem Cell 2021 Nov 4; 28(11):1896-1906
Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developmental potential as they progress from pre-implantation through post-implantation stages of development. Recent studies of cultured mouse and human pluripotent stem cells (hPSCs) have identified cells representative of an intermediate stage (referred to as the formative state) between naive pluripotency (equivalent to pre-implantation epiblast) and primed pluripotency (equivalent to late post-implantation epiblast). We examine these recent findings in light of our knowledge of peri-implantation mouse and human development, and we consider the implications of this work for deriving human embryo models from pluripotent cells.
Pera, Martin and Rossant, Janet, "The exploration of pluripotency space: Charting cell state transitions in peri-implantation development." (2021). Faculty Research 2021. 257.