The exploration of pluripotency space: Charting cell state transitions in peri-implantation development.
Document Type
Article
Publication Date
11-4-2021
Publication Title
Cell Stem Cell
Keywords
JMG, Animals, Cell Differentiation, Embryo Implantation, Embryo, Mammalian, Germ Layers, Humans, Mice, Pluripotent Stem Cells
JAX Source
Cell Stem Cell 2021 Nov 4; 28(11):1896-1906
Volume
28
Issue
11
First Page
1896
Last Page
1906
ISSN
1875-9777
PMID
34672948
DOI
https://doi.org/10.1016/j.stem.2021.10.001
Abstract
Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developmental potential as they progress from pre-implantation through post-implantation stages of development. Recent studies of cultured mouse and human pluripotent stem cells (hPSCs) have identified cells representative of an intermediate stage (referred to as the formative state) between naive pluripotency (equivalent to pre-implantation epiblast) and primed pluripotency (equivalent to late post-implantation epiblast). We examine these recent findings in light of our knowledge of peri-implantation mouse and human development, and we consider the implications of this work for deriving human embryo models from pluripotent cells.
Recommended Citation
Pera M,
Rossant J.
The exploration of pluripotency space: Charting cell state transitions in peri-implantation development. Cell Stem Cell 2021 Nov 4; 28(11):1896-1906