Document Type
Article
Publication Date
1-21-2021
Keywords
JMG
JAX Source
Front Aging Neurosci 2021 Jan 21; 12:607685
Volume
12
First Page
607685
Last Page
607685
ISSN
1663-4365
PMID
33551788
DOI
https://doi.org/10.3389/fnagi.2020.607685
Grant
AG057914,AG063755,AG054180
Abstract
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.
Recommended Citation
McQuail J,
Dunn A,
Stern Y,
Barnes C,
Kempermann G,
Rapp P,
Kaczorowski C,
Foster T.
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies. Front Aging Neurosci 2021 Jan 21; 12:607685
Comments
This is an open access article under the terms of the Creative Commons Attribution License.