Document Type

Article

Publication Date

1-21-2021

Keywords

JMG

JAX Source

Front Aging Neurosci 2021 Jan 21; 12:607685

PMID

33551788

DOI

https://doi.org/10.3389/fnagi.2020.607685

Grant

AG057914,AG063755,AG054180

Abstract

The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.

Comments

This is an open access article under the terms of the Creative Commons Attribution License.

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