Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models.
Document Type
Article
Publication Date
3-5-2021
Keywords
JMG
JAX Source
J Proteome Res 2021 Mar 5; 20(3)1733-1743
Volume
20
Issue
3
First Page
1733
Last Page
1743
ISSN
1535-3907
PMID
33534581
DOI
https://doi.org/10.1021/acs.jproteome.0c00934
Grant
AG051496, AG055104
Abstract
Extracellular vesicles (EVs) are secreted by any neural cells in the central nervous system for molecular clearance, cellular communications, and disease spread in multiple neurodegenerative diseases, including Alzheimer's disease (AD), although their exact molecular mechanism is poorly understood. We hypothesize that high-resolution proteomic profiling of EVs separated from animal models of AD would determine the composition of EV contents and their cellular origin. Here, we examined recently developed transgenic mice (CAST.
Recommended Citation
Muraoka S,
Jedrychowski M,
Iwahara N,
Abdullah M,
Onos KD,
Keezer K,
Hu J,
Ikezu S,
Howell G,
Gygi S,
Ikezu T.
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res 2021 Mar 5; 20(3)1733-1743