Title

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models.

Document Type

Article

Publication Date

3-5-2021

Keywords

JMG

JAX Source

J Proteome Res 2021 Mar 5; 20(3)1733-1743

Volume

20

Issue

3

First Page

1733

Last Page

1743

ISSN

1535-3907

PMID

33534581

DOI

https://doi.org/10.1021/acs.jproteome.0c00934

Grant

AG051496, AG055104

Abstract

Extracellular vesicles (EVs) are secreted by any neural cells in the central nervous system for molecular clearance, cellular communications, and disease spread in multiple neurodegenerative diseases, including Alzheimer's disease (AD), although their exact molecular mechanism is poorly understood. We hypothesize that high-resolution proteomic profiling of EVs separated from animal models of AD would determine the composition of EV contents and their cellular origin. Here, we examined recently developed transgenic mice (CAST.

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