Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics.
Document Type
Article
Publication Date
3-2021
Keywords
JMG
JAX Source
Trends Genet 2021 Mar; 37(3):251-265
Volume
37
Issue
3
First Page
251
Last Page
265
ISSN
0168-9525
PMID
33010949
DOI
https://doi.org/10.1016/j.tig.2020.09.007
Grant
OD011102, ES029916
Abstract
Interrogation of disease-relevant cellular and molecular traits exhibited by genetically diverse cell populations enables in vitro systems genetics approaches for uncovering the basic properties of cellular function and identity. Primary cells, stem cells, and organoids derived from genetically diverse mouse strains, such as Collaborative Cross and Diversity Outbred populations, offer the opportunity for parallel in vitro/in vivo screening. These panels provide genetic resolution for variant discovery and functional characterization, as well as disease modeling and in vivo validation capabilities. Here we review mouse cellular systems genetics approaches for characterizing the influence of genetic variation on signaling networks and phenotypic diversity, and we discuss approaches for data integration and cross-species validation.
Recommended Citation
Swanzey E,
O'Connor C,
Reinholdt L.
Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics. Trends Genet 2021 Mar; 37(3):251-265
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Comments
We thank Jason Stumpff, Steve Munger, and Catherine Kaczorowski for discussion and insightful comments on this review.
Cellular systems genetics research in the Reinholdt laboratory is currently supported by grants from The Jackson Laboratory.