Title

Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics.

Document Type

Article

Publication Date

3-2021

Keywords

JMG

JAX Source

Trends Genet 2021 Mar; 37(3):251-265

PMID

33010949

DOI

https://doi.org/10.1016/j.tig.2020.09.007

Grant

OD011102, ES029916

Abstract

Interrogation of disease-relevant cellular and molecular traits exhibited by genetically diverse cell populations enables in vitro systems genetics approaches for uncovering the basic properties of cellular function and identity. Primary cells, stem cells, and organoids derived from genetically diverse mouse strains, such as Collaborative Cross and Diversity Outbred populations, offer the opportunity for parallel in vitro/in vivo screening. These panels provide genetic resolution for variant discovery and functional characterization, as well as disease modeling and in vivo validation capabilities. Here we review mouse cellular systems genetics approaches for characterizing the influence of genetic variation on signaling networks and phenotypic diversity, and we discuss approaches for data integration and cross-species validation.

Comments

We thank Jason Stumpff, Steve Munger, and Catherine Kaczorowski for discussion and insightful comments on this review.

Cellular systems genetics research in the Reinholdt laboratory is currently supported by grants from The Jackson Laboratory.

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