Identification of cell-surface glycans that mediate motility-dependent binding and internalization of Pseudomonas aeruginosa by phagocytes.
Document Type
Article
Publication Date
3-2021
Keywords
JMG, Cell Line, Tumor, Cells, Cultured, HL-60 Cells, Heparitin Sulfate, Humans, Immunity, Innate, Interleukin-1beta, Monocytes, Phagocytes, Phagocytosis, Polysaccharides, Pseudomonas Infections, Pseudomonas aeruginosa, THP-1 Cells
JAX Source
Mol Immunol 2021 Mar; 131:68-77
Volume
131
First Page
68
Last Page
77
ISSN
1872-9142
PMID
33358569
DOI
https://doi.org/10.1016/j.molimm.2020.12.012
Abstract
Phagocytic cells are critical to host defense against Pseudomonas aeruginosa, a Gram-negative bacterium that is an opportunistic pathogen. Accordingly, susceptible individuals frequently have impaired innate immune responses, including those with cystic fibrosis or neutropenia. Previous studies identified that the downregulation, or loss, of bacterial flagellar motility enables bacteria to evade interactions with phagocytic cells that result in phagocytic uptake of the bacteria. However, the mechanistic bases for motility-dependent interactions between P. aeruginosa and host cell surfaces that lead to phagocytic uptake of the bacteria are poorly understood. A recent insight is that exogenous addition of a negatively charged phospholipid, phosphatidylinositol-(3,4,5)-triphosphate (PIP
Recommended Citation
Sanchez H,
Hopkins D,
Demirdjian S,
Gutierrez C,
O'Toole G,
Neelamegham S,
Berwin B.
Identification of cell-surface glycans that mediate motility-dependent binding and internalization of Pseudomonas aeruginosa by phagocytes. Mol Immunol 2021 Mar; 131:68-77