Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH.
Document Type
Article
Publication Date
4-7-2021
Publication Title
Neuron
Keywords
JGM, Alzheimer Disease, Genetic Engineering, Humans, Induced Pluripotent Stem Cells, Neural Stem Cells, Neurodegenerative Diseases, Stem Cell Research, Stem Cell Transplantation
JAX Source
Neuron 2021 Apr 7; 109(7):1080-1083
Volume
109
Issue
7
First Page
1080
Last Page
1083
ISSN
1097-4199
PMID
33831364
DOI
https://doi.org/10.1016/j.neuron.2021.03.022
Abstract
The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
Recommended Citation
Ramos D,
Skarnes W,
Singleton A,
Cookson M,
Ward M.
Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH. Neuron 2021 Apr 7; 109(7):1080-1083
Comments
We thank Erika Lara Flores, Andy Qi, Luke Reilly, Mike Nalls, Lirong Peng, Faraz Faghri, Jizhong Zou, Kailyn Anderson, Julia Stadler, Caroline Pantazis, Bruce Conklin, the Chan Zuckerberg Initiative, and the Allen Institute for their helpful input on this project and manuscript.