Document Type
Article
Publication Date
3-31-2021
Publication Title
Aging cell
Keywords
JMG
JAX Source
Aging Cell 2021 Mar 31; 20:e13328
First Page
13328
Last Page
13328
ISSN
1474-9726
PMID
33788371
DOI
https://doi.org/10.1111/acel.13328
Grant
AG02308, CA034196, AG013319, AG022303, AG022307
Abstract
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the "non-feminizing" estrogen, 17-α-estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log-rank test) and 11% (p = 0.007) when fed at 14.4 ppm starting at 16 and 20 months, respectively. 90th percentile lifespans were extended 7% (p = 0.004, Wang-Allison test) and 5% (p = 0.17). Body weights were reduced about 20% after starting the 17aE2 diets. Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranylacetone, and MIF098. Despite some data suggesting that nicotinamide riboside would be effective, neither it nor the other three increased lifespans significantly at the doses tested. The 17aE2 results confirm and extend our original reports, with very similar results when started at 16 months compared with mice started at 10 months of age in a prior study. The consistently large lifespan benefit in males, even when treatment is started late in life, may provide information on sex-specific aspects of aging.
Recommended Citation
Harrison D,
Strong R,
Reifsnyder PC,
Kumar N,
Fernandez E,
Flurkey K,
Javors M,
Lopez-Cruzan M,
Macchiarini F,
Nelson J,
Bitto A,
Sindler A,
Cortopassi G,
Kavanagh K,
Leng L,
Bucala R,
Rosenthal N,
Salmon A,
Stearns T,
Bogue MA,
Miller R.
17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell 2021 Mar 31; 20:e13328
Comments
This is an open access article under the terms of the Creative Commons Attribution License