Document Type

Article

Publication Date

5-11-2021

Publication Title

Stem Cell Reports

Keywords

JMG

JAX Source

Stem Cell Reports 2021 May 11; 16(5):1021-1030

Volume

16

Issue

5

First Page

1021

Last Page

1030

ISSN

2213-6711

PMID

33979591

DOI

https://doi.org/10.1016/j.stemcr.2021.03.023

Abstract

In recent years, a diverse array of in vitro cell-derived models of mammalian development have been described that hold immense potential for exploring fundamental questions in developmental biology, particularly in the case of the human embryo where ethical and technical limitations restrict research. These models open up new avenues toward biomedical advances in in vitro fertilization, clinical research, and drug screening with potential to impact wider society across many diverse fields. These technologies raise challenging questions with profound ethical, regulatory, and social implications that deserve due consideration. Here, we discuss the potential impacts of embryo-like models, and their biomedical potential and current limitations.

Comments

This is an open access article under the CC BY-NC-ND license.

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