BMC immunology [electronic resource]
BMC Immunol 2021 May 17; 22(1):32
BACKGROUND: Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88
CONCLUSION: Our findings show that MyD88 signaling enhances, but is not required, for bacterial uptake or phagosomal maturation and provide mechanistic insights into how MyD88-mediated phagosomal signaling enhances Bb uptake and clearance.
Benjamin, Sarah J; Hawley, Kelly L; Vera-Licona, Paola; La Vake, Carson J; Cervantes, Jorge L; Ruan, Yijun; Radolf, Justin D; and Salazar, Juan C, "Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation." (2021). Faculty Research 2021. 97.