Single-cell transcriptomics defines Dot1L interacting partners and downstream target genes in the mouse molar dental pulp.
Document Type
Article
Publication Date
1-1-2022
Original Citation
Guzzo R,
Enkhmandakh B,
Becker T,
Joshi P,
Robson P,
Vijaykumar A,
Mina M,
Shin D,
Bayarsaihan D.
Single-cell transcriptomics defines Dot1L interacting partners and downstream target genes in the mouse molar dental pulp. Int J Dev Biol. 2022;66(7-8-9):391-400.
Keywords
JGM, Animals, Mice, Methyltransferases, Transcription Factors, Transcriptome, Dental Pulp, Endothelial Cells, Nuclear Proteins, Osteogenesis, Histone-Lysine N-Methyltransferase
JAX Source
Int J Dev Biol. 2022;66(7-8-9):391-400.
ISSN
1696-3547
PMID
36942693
DOI
https://doi.org/10.1387/ijdb.220141db
Grant
This project was funded by the grant REP-401754-20144-20 from the university of connecticut to dB.
Abstract
Although histone methyltransferases are implicated in many key developmental processes, the contribution of individual chromatin modifiers in dental tissues is not well understood. Using single-cell RNA sequencing, we examined the expression profiles of the disruptor of telomeric silencing 1-like (