Clonal hematopoiesis, aging and Alzheimer's disease.
Document Type
Article
Publication Date
7-1-2023
Original Citation
Sánchez Vela P,
Trowbridge JJ,
Levine R.
Clonal hematopoiesis, aging and Alzheimer's disease. Nat Med. 2023;29(7):1605-6.
Keywords
JMG, Humans, Clonal Hematopoiesis, Alzheimer Disease, Aging, Hematopoiesis, Mutation, Cardiovascular Diseases
JAX Source
Nat Med. 2023;29(7):1605-6.
ISSN
1546-170X
PMID
37402877
DOI
https://doi.org/10.1038/s41591-023-02406-4
Grant
Work in the Levine Lab is supported by US National Institutes of Health–National Cancer Institute Cancer Center Support Grant P30 CA008748, and work in the Trowbridge and Levine labs is supported by National Cancer Institute–National Institute on Aging grant U01AG077925-01. The Trowbridge lab is supported by US National Institutes of Health– National Cancer Institute Cancer Center Support Grant P30 CA034196, US National Institutes of Health grants R01DK118072 and R01AG069010, EvansMDS, and The Mark Foundation. J.J.T. is a Scholar of the Leukemia & Lymphoma Society. P.S.V. is supported by a grant from Cycle for Survival at Memorial Sloan Kettering Cancer Center and was previously supported by the Mark Foundation.
Abstract
Unexpectedly, new data show that clonal hematopoiesis is associated with protection from Alzheimer’s disease; it is imperative that future studies unravel the complex tissue– disease contexts in which clonal hematopoiesis arises and contributes to aging-associated diseases.