Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration.
Document Type
Article
Publication Date
1-1-2023
Original Citation
Gogna N,
Hyde L,
Collin GB,
Stone L,
Naggert J,
Nishina PM.
Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration. Adv Exp Med Biol. 2023
Keywords
JMG, Humans, Aged, Proteins, Serine Endopeptidases, Genome-Wide Association Study, High-Temperature Requirement A Serine Peptidase 1, Macular Degeneration, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Complement Factor H, Genotype
JAX Source
Adv Exp Med Biol. 2023
ISSN
0065-2598
PMID
37440010
DOI
https://doi.org/10.1007/978-3-031-27681-1_5
Abstract
Age-related macular degeneration (AMD) is the leading cause of blindness in the global aging population. Familial aggregation and genome-wide association (GWA) studies have identified gene variants associated with AMD, implying a strong genetic contribution to AMD development. Two loci, on human Chr 1q31 and 10q26, respectively, represent the most influential of all genetic factors. While the role of CFH at Chr 1q31 is well established, uncertainty remains about the genes ARMS2 and HTRA1, at the Chr 10q26 locus. Since both genes are in strong linkage disequilibrium, assigning individual gene effects is difficult. In this chapter, we review current literature about ARMS2 and HTRA1 and their relevance to AMD risk. Future studies will be necessary to unravel the mechanisms by which they contribute to AMD.