Skin microbiome attributes associate with biophysical skin ageing.
Document Type
Article
Publication Date
9-1-2023
Original Citation
Zhou W,
Fleming E,
Legendre G,
Roux L,
Latreille J,
Gendronneau G,
Forestier S,
Oh J.
Skin microbiome attributes associate with biophysical skin ageing. Exp Dermatol. 2023;32(9):1546-56.
Keywords
Skin Aging, Microbiota, Bacteria, Anti-Bacterial Agents, Skin
JAX Source
Exp Dermatol. 2023;32(9):1546-56.
ISSN
1600-0625
PMID
37350224
DOI
https://doi.org/10.1111/exd.14863
Grant
This work was supported by Chanel Parfums Beauté, Paris, France. We gratefully acknowledge the contribution of the Genome Technologies service and cyberinfrastructure high-performance computing resources at The Jackson Laboratory (JAX) for expert assistance with the work described herein. These shared services were supported in part by the JAX Cancer Center (P30 CA034196). JO was additionally supported by R56 AG060746-01A1, 1DP2GM126893-01, 1 R01 AR078634-01 and 5 R21 AR075174-02.
Abstract
Two major arms of skin ageing are changes in the skin's biophysical conditions and alterations in the skin microbiome. This work partitioned both arms to study their interaction in detail. Leveraging the resolution provided by shotgun metagenomics, we explored how skin microbial species, strains and gene content interact with the biophysical traits of the skin during ageing. With a dataset well-controlled for confounding factors, we found that skin biophysical traits, especially the collagen diffusion coefficient, are associated with the composition and the functional potential of the skin microbiome, including the abundance of bacterial strains found in nosocomial infections and the abundance of antibiotic resistance genes. Our findings reveal important associations between skin biophysical features and ageing-related changes in the skin microbiome and generate testable hypotheses for the mechanisms of such associations.