Pre-Covid-19, SARS-CoV-2-Negative Multisystem Inflammatory Syndrome in Children.

Document Type

Article

Publication Date

11-30-2023

Keywords

JGM, Child, Humans, COVID-19, SARS-CoV-2, Systemic Inflammatory Response Syndrome

JAX Source

N Engl J Med. 2023;389(22):2105-7.

ISSN

1533-4406

PMID

38048195

DOI

https://doi.org/10.1056/NEJMc2307574

Abstract

To The Editor:

In early 2020, multisystemic inflammatory syndrome in children (MIS-C) was recognized as an emerging life-threatening disease occurring 2 to 6 weeks after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with symptoms resembling those of Kawasaki’s disease or toxic shock syndrome.1 Unlike typical Kawasaki’s disease, MIS-C has been frequently associated with gastrointestinal symptoms and circulatory failure necessitating treatment with vasoactive drugs.

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