Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids.
Document Type
Article
Publication Date
12-19-2023
Original Citation
Zheng J,
Sun B,
Berardi D,
Lu L,
Yan H,
Zheng S,
Aladelokun O,
Xie Y,
Cai Y,
Godri Pollitt K,
Khan S,
Johnson C.
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environ Sci Technol. 2023;57(50):21016-28.
Keywords
JGM, Humans, Proto-Oncogene Proteins p21(ras), Fluorocarbons, Alkanesulfonic Acids, Caprylates, Colorectal Neoplasms
JAX Source
Environ Sci Technol. 2023;57(50):21016-28.
ISSN
1520-5851
PMID
38064429
DOI
https://doi.org/10.1021/acs.est.3c04844
Abstract
Perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are persistent environmental contaminants that are of increasing public concern worldwide. However, their relationship with colorectal cancer (CRC) is poorly understood. This study aims to comprehensively investigate the effect of PFOS and PFOA on the development and progression of CRC