Document Type

Article

Publication Date

12-1-2023

Keywords

JMG, Humans, Aged, Urinary Bladder, Quality of Life, Urinary Tract, Aging, Brain

JAX Source

Aging Cell. 2023;22(12):e13990.

ISSN

1474-9726

PMID

37740454

DOI

https://doi.org/10.1111/acel.13990

Grant

Drs Kenneth and Beverly Paigen Endowment (The Jackson Lab); National Institute on Aging, Grant/Award Number: AG038070, AG062409 and AG079753

Abstract

Age-associated alterations in bladder control affect millions of older adults, with a heavy burden added to families both economically and in quality of life. Therapeutic options are limited with poor efficacy in older adults, lending to a growing need to address the gaps in our current understanding of urinary tract aging. This review summarizes the current knowledge of age-associated alterations in the structure and function of the brain-bladder axis and identifies important gaps in the field that have yet to be addressed. Urinary aging is associated with decreased tissue responsiveness, decreased control over the voiding reflex, signaling dysfunction along the brain-bladder axis, and structural changes within the bladder wall. Studies are needed to improve our understanding of how age affects the brain-bladder axis and identify genetic targets that correlate with functional outcomes.

Comments

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

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