Document Type

Article

Publication Date

12-5-2023

Keywords

JMG, Mice, Humans, Animals, Diabetes Mellitus, Type 1, CD8-Positive T-Lymphocytes, Mice, Inbred NOD, Mammary Tumor Virus, Mouse, Mice, Inbred C57BL, Receptors, Antigen, T-Cell, CD4-Positive T-Lymphocytes, Mice, Transgenic

JAX Source

Proc Natl Acad Sci U S A. 2023;120(49):e2312039120.

ISSN

1091-6490

PMID

38015847

DOI

https://doi.org/10.1073/pnas.2312039120

Grant

These studies were financially supported by American Diabetes Association grant 1-14-BS-051 (J.P.D.), NIH grant AI130656 (Y.-G.C. and J.P.D.), NIH grant DK-95735 (D.V.S.), NIH grant OD-5U4OD020351 (D.V.S.), and Mark Foundation for Cancer Research Grant 21-010-PPM (D.V.S.).

Abstract

In both humans and NOD mice, type 1 diabetes (T1D) develops from the autoimmune destruction of pancreatic beta cells by T cells. Interactions between both helper CD4

Comments

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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