Document Type

Article

Publication Date

12-1-2022

JAX Source

Addict Neurosci. 2022;4.

ISSN

2772-3925

PMID

36714272

DOI

https://doi.org/10.1016/j.addicn.2022.100045

Grant

These studies were supported, in part, by Public Health Service grants [P50-DA039841](EJC, JDJ, LGR, LMT), [P30-CA034196] (Lutz, Cathleen M.; VMP) and [T32-AA025606] (JDJ and JRB). The authors have no conflicts of interest to declare.

Abstract

Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated with risk for substance use disorders. Identifying the neurogenetic mechanisms that influence impulsivity may also reveal novel biological insights into addiction vulnerability. Our past studies using the BXD and Collaborative Cross (CC) recombinant inbred mouse panels have revealed that behavioral indicators of impulsivity measured in a reversal-learning task are heritable and are genetically correlated with aspects of intravenous cocaine self-administration. Genome-wide linkage studies in the BXD panel revealed a quantitative trait locus (QTL) on chromosome 10, but we expect to identify additional QTL by testing in a population with more genetic diversity. To this end, we turned to Diversity Outbred (DO) mice; 392 DO mice (156 males, 236 females) were phenotyped using the same reversal learning test utilized previously. Our primary indicator of impulsive responding, a measure that isolates the relative difficulty mice have with reaching performance criteria under reversal conditions, revealed a genome-wide significant QTL on chromosome 7 (max LOD score = 8.73, genome-wide corrected p

Comments

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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