Document Type
Article
Publication Date
5-30-2024
Original Citation
Werren E,
Peirent E,
Jantti H,
Guxholli A,
Srivastava K,
Orenstein N,
Narayanan V,
Wiszniewski W,
Dawidziuk M,
Gawlinski P,
Umair M,
Khan A,
Khan S,
Geneviève D,
Lehalle D,
van Gassen K,
Giltay J,
Oegema R,
van Jaarsveld R,
Rafiullah R,
Rappold G,
Rabin R,
Pappas J,
Wheeler M,
Bamshad M,
Tsan Y,
Johnson M,
Keegan C,
Srivastava A,
Bielas S.
Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations. Cell Death Dis. 2024;15(5):379.
Keywords
JGM, Humans, Intellectual Disability, Membrane Proteins, Female, Male, Neurodevelopmental Disorders, Alleles, Malformations of Cortical Development, Child, Child, Preschool, Cell Differentiation, Tumor Suppressor Proteins
JAX Source
Cell Death Dis. 2024;15(5):379.
ISSN
2041-4889
PMID
38816421
DOI
https://doi.org/10.1038/s41419-024-06768-6
Abstract
CSMD1 (Cub and Sushi Multiple Domains 1) is a well-recognized regulator of the complement cascade, an important component of the innate immune response. CSMD1 is highly expressed in the central nervous system (CNS) where emergent functions of the complement pathway modulate neural development and synaptic activity. While a genetic risk factor for neuropsychiatric disorders, the role of CSMD1 in neurodevelopmental disorders is unclear. Through international variant sharing, we identified inherited biallelic CSMD1 variants in eight individuals from six families of diverse ancestry who present with global developmental delay, intellectual disability, microcephaly, and polymicrogyria. We modeled CSMD1 loss-of-function (LOF) pathogenesis in early-stage forebrain organoids differentiated from CSMD1 knockout human embryonic stem cells (hESCs). We show that CSMD1 is necessary for neuroepithelial cytoarchitecture and synchronous differentiation. In summary, we identified a critical role for CSMD1 in brain development and biallelic CSMD1 variants as the molecular basis of a previously undefined neurodevelopmental disorder.
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