Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms

Document Type

Article

Publication Date

5-2024

Keywords

JGM

JAX Source

Frailty: A Multidisciplinary Approach to Assessment, Management, and Prevention. Cham: Springer International Publishing; 2024. p. 109-17.

DOI

https://doi.org/10.1007/978-3-031-57361-3_15

Abstract

The human body is colonized on nearly every external and internal surface by communities of microbes including bacteria, viruses, fungi, archaea, and eukarya, called microbiota. The sum of commensal microbial genes outnumbers human host genes by over 100-fold. Next generation sequencing technology has facilitated over two decades of study characterizing the relationship between this metagenome and virtually every dimension of human health, including obesity, heart disease, diabetes mellitus, cancers, inflammatory dis- eases, and neurological disorders [1–7]. Further investigation of molecular interactions between host and microbiota has elucidated diverse mechanisms by which these communities influence and are influenced by human health and disease. This chapter aims to summarize our present understanding of microbiome associations with frailty, the proposed pathways by which the microbiota may influence the development of physical frailty, and potential implications.

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