Document Type
Article
Publication Date
5-7-2024
Original Citation
Baldarelli RM,
Smith C,
Ringwald M,
Richardson J,
Bult C,
.
Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse. Genetics. 2024;227(1):iyae031.
Keywords
JMG, Animals, Mice, Databases, Genetic, Genome, Knowledge Bases, Genomics, Computational Biology, Humans
JAX Source
Genetics. 2024;227(1):iyae031.
ISSN
1943-2631
PMID
38531069
DOI
https://doi.org/10.1093/genetics/iyae031
Grant
This work was made possible by NIH grant HG000330 from the National Human Genome Research Institute, grant HD062499 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and grant OD011190 from the Office of the Director, Division of Comparative Medicine
Abstract
Mouse Genome Informatics (MGI) is a federation of expertly curated information resources designed to support experimental and computational investigations into genetic and genomic aspects of human biology and disease using the laboratory mouse as a model system. The Mouse Genome Database (MGD) and the Gene Expression Database (GXD) are core MGI databases that share data and system architecture. MGI serves as the central community resource of integrated information about mouse genome features, variation, expression, gene function, phenotype, and human disease models acquired from peer-reviewed publications, author submissions, and major bioinformatics resources. To facilitate integration and standardization of data, biocuration scientists annotate using terms from controlled metadata vocabularies and biological ontologies (e.g. Mammalian Phenotype Ontology, Mouse Developmental Anatomy, Disease Ontology, Gene Ontology, etc.), and by applying international community standards for gene, allele, and mouse strain nomenclature. MGI serves basic scientists, translational researchers, and data scientists by providing access to FAIR-compliant data in both human-readable and compute-ready formats. The MGI resource is accessible at https://informatics.jax.org. Here, we present an overview of the core data types represented in MGI and highlight recent enhancements to the resource with a focus on new data and functionality for MGD and GXD.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.