Document Type
Article
Publication Date
7-2-2024
Original Citation
Teboul L,
Amos-Landgraf J,
Benavides F,
Birling M,
Brown S,
Bryda E,
Bunton-Stasyshyn R,
Chin H,
Crispo M,
Delerue F,
Dobbie M,
Franklin C,
Fuchtbauer E,
Gao X,
Golzio C,
Haffner R,
Hérault Y,
Hrabe de Angelis M,
Lloyd K,
Magnuson T,
Montoliu L,
Murray SA,
Nam K,
Nutter L,
Pailhoux E,
Pardo Manuel de Villena F,
Peterson K,
Reinholdt L,
Sedlacek R,
Seong J,
Shiroishi T,
Smith C,
Takeo T,
Tinsley L,
Vilotte J,
Warming S,
Wells S,
Whitelaw C,
Yoshiki A,
,
,
,
,
,
,
,
,
,
Pavlovic G.
Improving laboratory animal genetic reporting: LAG-R guidelines. Nat Commun. 2024;15(1):5574.
Keywords
JMG, Animals, Animals, Laboratory, Guidelines as Topic, Reproducibility of Results, Research Design, Animal Experimentation, Biomedical Research
JAX Source
Nat Commun. 2024;15(1):5574.
ISSN
2041-1723
PMID
38956430
DOI
https://doi.org/10.1038/s41467-024-49439-y
Abstract
The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.