Document Type

Article

Publication Date

3-1-2024

Keywords

Humans, Mice, Male, Female, Animals, Triglycerides, Calcium, Cross-Sectional Studies, Dietary Carbohydrates, Cholesterol, Sucrose

JAX Source

FEBS Open Bio. 2024;14(3):426-33.

ISSN

2211-5463

PMID

38129969

DOI

https://doi.org/10.1002/2211-5463.13757

Grant

Funding for this work was acquired by DB and GAC.

Abstract

Genetically diverse outbred mice allow for the study of genetic variation in the context of high dietary and environmental control. Using a machine learning approach, we investigated clinical and morphometric factors that associate with serum cholesterol levels in 840 genetically unique Diversity Outbred mice of both sexes (n = 417 male and 423 female), and on both a control chow (% kcals in diet: protein 22%, carbohydrate 62%, fat 16%, no cholesterol) and high fat high sucrose (% kcals in diet: protein 15%, carbohydrate 41%, fat 45%, 0.05% cholesterol). We find expected elevations of cholesterol in male mice, as well as in mice with elevated serum triglycerides and/or fed a high fat high sucrose diet. The third strongest predictor was serum calcium which correlated with serum cholesterol across both diets and sexes (r = 0.39-0.48) in both Diversity Outbred (P = 3.0 × 10

Comments

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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