Document Type

Article

Publication Date

1-1-2024

Keywords

JGM, Humans, Melanoma, Skin Neoplasms, Base Sequence, Biomarkers, RNA

JAX Source

Front Public Health. 2024;12:1328089.

ISSN

2296-2565

PMID

38444441

DOI

https://doi.org/10.3389/fpubh.2024.1328089

Abstract

BACKGROUND: Ultraviolet B (UVB) from sunlight represents a major environmental factor that causes toxic effects resulting in structural and functional cutaneous abnormalities in most living organisms. Although numerous studies have indicated the biological mechanisms linking UVB exposure and cutaneous manifestations, they have typically originated from a single study performed under limited conditions.

METHODS: We accessed all publicly accessible expression data of various skin cell types exposed to UVB, including skin biopsies, keratinocytes, and fibroblasts. We performed biological network analysis to identify the molecular mechanisms and identify genetic biomarkers.

RESULTS: We interpreted the inflammatory response and carcinogenesis as major UVB-induced signaling alternations and identified three candidate biomarkers (

CONCLUSION: Our findings will aid the understanding of UVB-induced cutaneous toxicity and the accompanying molecular mechanisms. In addition, the three candidate biomarkers that change molecular signals due to UVB exposure of skin might be related to the survival rate of patients with cutaneous melanoma.

Comments

© 2024 Jang, Na, Shin, Lee, Han, Kim, Kim, Choi, Lee, Hong, Kim and Seo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms

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