Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200

Authors

• Yusuke Takeuchi
• Daiya Ohara
• Hitomi Watanabe
• Yuji Nishimura
• Takeshi Iwasaki, The Jackson LaboratoryFollow
• Shohei Hori
• Hiroshi Kawamoto
• Hiroki Kato
• Gen Kondoh
• Akio Morinobu
• Tsuneyo Mimori
• Keiji Hirota

Document Type

Article

Publication Date

4-1-2026

Original Citation

Takeuchi Y, Ohara D, Watanabe H, Nishimura Y, Iwasaki T, Hori S, Kawamoto H, Kato H, Kondoh G, Morinobu A, Mimori T, Hirota K. Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200 Nat Immunol. 2026;27(4):841–53.

Keywords

JMG, Animals, Th17 Cells, Early Growth Response Protein 2, Receptors, Antigen, T-Cell, Mice, Antigens, CD, Arthritis, Experimental, T-Lymphocytes, Regulatory, Signal Transduction, Cell Differentiation, Mice, Inbred C57BL, Mice, Knockout, Joints, Integrin alpha Chains

JAX Source

Nat Immunol. 2026;27(4):841–53.

ISSN

1529-2916

PMID

41872507

DOI

https://doi.org/10.1038/s41590-026-02447-0

Abstract

Excessive activation of interleukin-17-producing helper T (T