Submissions from 2026
IL1A enhances TNF-induced retinal ganglion cell death., Katherine M Andersh, Michael MacLean, Gareth R Howell, and Richard T Libby
Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory., Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia J Marola, Christopher M Norris, Alaina M Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth R Howell, and Cheryl L Wellington
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia., Alexander Arnuk, Cuijuan Han, Abimbola Eunice Lawal, Bofei Wang, Sadik Karma, Zhiping Zhang, Mhd Yousuf Yassouf, Sakthi Harini Rajendran, Harshpreet Chandok, Madeline L Eller, Sogand Sajedi, Meryl McKenna, Eve Herman, Louisa Hagen, Bettina Nadorp, Zengshuo Mo, Hector Orellana, Aristotelis Tsirigos, Pedro Miura, Hussein A Abbas, Iannis Aifantis, and Eric Wang
Roads and detours for CAR T cell therapy in autoimmune diseases., Jérôme Avouac, Adi Barzel, Delma Caiati, Randall S Davis, Stephen Gottschalk, Ricardo Grieshaber-Bouyer, Xuming Mao, Eline T Luning Prak, Marko Radic, Marc Scherlinger, Yatin Suneja, Aimee Talleur, Amber L Thacker, and Derya Unutmaz
The DO-KB knowledgebase 2026 update: expanding programmatic and language access., J Allen Baron, Claudia M Sánchez-Beato Johnson, Michael A Schor, Dustin Olley, Lance Nickel, Victor Felix, Susan M. Bello, Carol Greene, Richard Lichenstein, Katharine Bisordi, Rima Koka, Cynthia Bearer, Regina Macatangay, Nischal Ada, Kaitlin Ballenger, Emily Bliss, Lauren Colliver, Grace Dobbins, Harrison Heitzig, Shannan Dixon, Patrick Semesky, Jennifer Garth, Matthew Fairchild, Peter Gaskin, Sarina Zahid, Rachel Castillo, Sarah Edwards, Astrid Widjaja, Yamei Usui, Erin Lynch, Melissa Clarkson, Todd Detwiler, and Lynn M Schriml
Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction., Laura Blanco-Berdugo, Alexis Garretson, and Beth L Dumont
Views and experiences regarding workplace genetic testing: findings from a national survey of U.S. employees., Drew Blasco, Sarah McCain, Subhamoy Pal, Wendy R Uhlmann, Rebecca Ferber, Kunal Sanghavi, Elizabeth Charnysh, Anya E R Prince, Charles Lee, J Scott Roberts, and the INSIGHT @ Work Consortium
From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood., Lauren G Brown, Xiaofu Wei, Laura A Milton, M Yunos Alizai, James W MacDonald, Theo K Bammler, Yuting Zeng, Ingrid Robertson, Karen N Adams, Yi-Chin Toh, Damien Chaussabel, Erwin Berthier, Amanda J Haack, and Ashleigh B Theberge
Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study, Daniel R Carrizosa, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Deepti Behl, Bamidele Adesunloye, Evan Pisick, Kathleen W Beekman, Efrat Dotan, Mehmet Akce, Olatunji B Alese, Vaibhav Sahai, Kelsey A Klute, Jeanny B Aragon-Ching, Kathrine A Cooper, Ramya Thota, Funda Meric-Bernstam, Peter J Hosein, Erika C Maestas, Justin T Moyers, Steven Powell, Song Zhao, Evthokia Hobbs, Jens Rueter, Davendra P S Sohal, Mark A Taylor, Dominique C Hinshaw, Abigail Gregory, Gina N Grantham, Susan Halabi, and Richard L Schilsky
Beyond the streetlight: a TREAT-AD perspective on where to find new Alzheimer's targets., Gregory Cary, Jesse C Wiley, Gregory W. Carter, and Allan I Levey
JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse., Anshul Choudhary, Brian Q Geuther, Thomas J. Sproule, Glen L Beane, Vivek Kohar, Jarek Trapszo, and Vivek Kumar
Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, and Elena Gonzalo-Gil
Metallothionein 1 mediates growth and survival of Dnmt3a;Npm1-mutant acute myeloid leukemia, Patricia A Colom Díaz, Jayna J Mistry, Kira Young, Chih-Hsing Chou, Nathan Boyer, Ross L Levine, Nathan Salomonis, H Leighton Grimes, and Jennifer J. Trowbridge
Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment., Alex R DeCasien, Jacob E Aronoff, Elizabeth K Mallott, Sahana Kuthyar, Sriram Chitta, Brian T Layden, Maria L Savo Sardaro, Stanton Gray, Lawrence E Williams, Emma R Liechty, Hyo M Lee, Won Lee, James P Curley, Christopher W Kuzawa, and Katherine R Amato
African Domestic Poultry Genetic Resources, Diversity, and Unique Features, Tadelle Dessie, Christian K. Tiambo, Liveness J. Banda, Raman Akinyanju Lawal, Sheila C. Ommeh, Timothy Gondwe, Esatu Wondmeneh, Matthew A. Adeleke, and Olivier Hanotte
Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder., Brianna L DiSanza, Giulia S Porcari, Livia Sertori Finoti, Leonardo Ramos-Rodriguez, Devin M Burris, Justin A McDonough, Gang Ning, Grace Fagan, Guy T Helman, Erin Weiss, Ryan J Taft, Amy Pizzino, Matthew T Whitehead, Amy Waldman, Cas Simons, Xilma Ortiz-Gonzalez, William C Skarnes, Adeline Vanderver, Elizabeth J Bhoj, and Rebecca C Ahrens-Nicklas
Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape., Giovanna L Durante, Anna L. Tyler, Rod C Scott, Amanda E Hernan, and J Matthew Mahoney
Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, and Duygu Ucar
Improving rigor and reproducibility through implementation of the ISSCR standards for human stem cell use in research., Yvonne Fischer, Jack Mosher, Ivana Barbaric, Claudia Spits, and Martin Pera
New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity., Carrie A Flynn, Rebecca I Colón-Ríos, Andrew Harmez, William F Flynn, and Barbara I Kazmierczak
Prediction of outcome from spatial Protein profiling of triple-negative breast cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, and Jeffrey Chuang
PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function., Kayla Frank, Himani Sharma, Efthymios Motakis, Nooshin Nourbakhsh, Shawn Abeynaike, Tridu R Huynh, Cheryl A Jones, Scott K Johnson, S Mark Tompkins, and Silke Paust
Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis, Hussein Ghamlouch, Michaël Degaud, Veronique Della-Valle, Alexandre Eeckhoutte, Marine Armand, Amina Joudat, Camille Decaudin, Pilar M Dominguez, Wojciech Rosikiewicz, Patrycja Pawlikowska, Walaa Darwiche, Enguerran Mouly, Sheng Li, Ari M Melnick, Said Aoufouchi, and Olivier A Bernard
Mapping the genetic landscape across 14 psychiatric disorders., Andrew D Grotzinger, Josefin Werme, Wouter J Peyrot, Oleksandr Frei, Christiaan de Leeuw, Lucy K Bicks, Qiuyu Guo, Michael P Margolis, Brandon J Coombes, Anthony Batzler, Vanessa Pazdernik, Joanna M Biernacka, Ole A Andreassen, Verneri Anttila, Anders D Børglum, Gerome Breen, Na Cai, Ditte Demontis, Howard J Edenberg, Stephen V Faraone, Barbara Franke, Michael J Gandal, Joel Gelernter, Alexander S Hatoum, John M Hettema, Emma C Johnson, Katherine G Jonas, James A Knowles, Karestan C Koenen, Adam X Maihofer, Travis T Mallard, Manuel Mattheisen, Karen S Mitchell, Benjamin M Neale, Caroline M Nievergelt, John I Nurnberger, Kevin S O'Connell, Roseann E Peterson, Elise B Robinson, Sandra S Sanchez-Roige, Susan L Santangelo, Jeremiah M Scharf, Hreinn Stefansson, Kari Stefansson, Murray B Stein, Nora I Strom, Laura M Thornton, Elliot M Tucker-Drob, Brad Verhulst, Irwin D Waldman, G Bragi Walters, Naomi R Wray, Dongmei Yu, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nicotine Dependence GenOmics (INDIGO) Consortium, Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Phil H Lee, Kenneth S Kendler, and Jordan W Smoller
Ageing promotes microglial accumulation of slow-degrading synaptic proteins., Ian H Guldner, Viktoria P Wagner, Patricia Moran-Losada, Sophia M Shi, Sophia W Golub, Johannes F Hevler, Kelly Chen, Barbara T Meese, Ali Ghoochani, Ernst Pulido, Hamilton Se-Hwee Oh, Yann Le Guen, Nannan Lu, Pui Shuen Wong, Ning-Sum To, Dylan Garceau, Zimin Guo, Jian Luo, Carolyn R Bertozzi, Emma Lundberg, Monther Abu-Remaileh, Michael Sasner, Andreas Keller, Andrew C Yang, Tom H Cheung, and Tony Wyss-Coray
cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice., Suman Gupta, James Matsunaga, Bridget Ratitong, Andrew Manion, Sana Ismaeel, Diogo G Valadares, A Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj, Jenifer Coburn, Andrea J Wolf, Meghan A Morrissey, Suzanne L Cassel, David A Haake, and Fayyaz S Sutterwala
miRNA checking meiosis., Mary Ann Handel
A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex., Camille M Hanes, David M Steffen, George Murray, Robert W. Burgess, Joshua A Weiner, and Andrew M Garrett
A dual role for GLI3 signaling in neural crest development., Simon J Y Han, Vinit Adani, Edward Farrow, Bhaval Parmar, Ching-Fang Chang, Kim Cochran, Ronald R Horne, Paige J K Ramkissoon, Ezekiel Esteban, Kelsey H Elliott, Kevin A Peterson, Brian Gebelein, Martín I García-Castro, and Samantha A Brugmann
Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury., Zachary M Harris, Asawari Korde, Johad Khoury, Edward P Manning, Gail Stanley, Yosep Shin, Kennedy Mitchell, Alexa von der Schulenburg, Ying Sun, Buqu Hu, Hyeon Jun Shin, John Joerns, Brian Clark, Lindsey Placek, Derya Unutmaz, Aigul Moldobaeva, Lokesh Sharma, Maor Sauler, Govindarajan Rajagopalan, Xuchen Zhang, He Wang, Mahboobe Ghaedi, Min-Jong Kang, and Jonathan L Koff
High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape., Mohab Helmy, Jin U Li, Xinyu F Yan, Rachel K Meade, Elizabeth Anderson, Patrick B Chen, Anne M Czechanski, Tomás Di Domenico, Jonathan Flint, Erik Garrison, Marco T P Gontijo, Andrea Guarracino, Leanne Haggerty, Edith Heard, Kerstin Howe, Narendra Meena, Fergal J Martin, Eric A Miska, Isabell Rall, Navin B Ramakrishna, Alexandra Sapetschnig, Swati Sinha, Diandian Sun, Francesca F Tricomi, Runjia Qu, Jonathan M D Wood, Tianzhen Wu, Dian J Zhou, Laura G Reinholdt, David J Adams, Clare M Smith, Jingtao Lilue, and Thomas M Keane
TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi van Hijfte, Rania Head, Iris de Heer, Marta Padovan, Maurice de Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J van den Bent, Pieter Wesseling, and Pim J French
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting., Ari Itoh-Nakadai, Minggao Liang, Michiho Shindo, Chen Bibi, Mariko Tomizawa-Murasawa, Saera Fujiki, Akiko Kaneko, Emi Kanamaru, Mari Hashimoto, Hiroshi Kajita, Yoshinari Ando, Miki Kojima, Jonathan Moody, Makoto Iwasaki, Shinsuke Takagi, Ryo Nakagawa, Saumya Agrawal, Hanae Amitani-Iijima, Kaori Sato, Yuriko Sorimachi, Nahoko Suzuki, Takehiro Fukami, Kazuharu Hanada, Satoshi Morita, Kazushige Katsura, Takehisa Matsumoto, Maiko Kobayashi, Masahiko Kato, Yasuyuki Negishi, Mikako Shirouzu, Yuho Najima, Keiyo Takubo, Chung Chau Hon, Naoyuki Uchida, Shuichi Taniguchi, Yukihide Momozawa, Piero Carninci, Leonard D. Shultz, Yoriko Saito, Michiel de Hoon, Jay W Shin, and Fumihiko Ishikawa
GPR156 is required in sensory hair cells for proper auditory and vestibular function., Amandine Jarysta, Brandie Morris Verdone, Elli I Hartig, Kathleen E Cullen, and Basile Tarchini
Extrachromosomal DNA amplifications exhibit distinct molecular characteristics and prognostic implications in gastric cancer., Seunghyun Kang, Donghyeok Seol, Jieun Lee, Chanmi Bang, Mira Yoo, Soyeon Kim, Sepil An, Hyeongjin Cho, Duyeong Hwang, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Hyung-Ho Kim, Eunhee Yi, Sanghyun Kim, Yun-Suhk Suh, and Hoon Kim
Sex-specific proteostasis and urothelial responses to senolytic therapy in the aged mouse bladder., Sumiran Kasturi, Arnold M Salazar, Cara C Hardy, Ron Korstanje, and Indira U Mysorekar
Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, and Angelo D'Alessandro
Perspectives from the 2025 ISCBI/ISCI joint workshop on genetic stability, clonal monitoring, ethical data governance, and global inclusion in stem cell banking., Jung-Hyun Kim, Andreas Kurtz, Ivana Barbaric, Maneesha S Inamdar, Martin Pera, Nissim Benvenisty, Nika Shakiba, Rosario Isasi, Tadaaki Hanatani, and Glyn Stacey
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription., Minji Kim, Ping Wang, Patricia A Clow, Eli Chien, Xiaotao Wang, Jianhao Peng, Haoxi Chai, Xiyuan Liu, Byoungkoo Lee, Chew Yee Ngan, Olgica Milenkovic, Jeffrey Chuang, Chia-Lin Wei, Rafael Casellas, Albert Cheng, and Yijun Ruan
Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, ViLinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, and Erin C Hanlon
Improving gene isoform quantification with miniQuant., Haoran Li, Dingjie Wang, Qi Gao, Puwen Tan, Yunhao Wang, Xiaoyu Cai, Aifu Li, Yue Zhao, Andrew L Thurman, Seyed Amir Malekpour, Ying Zhang, Roberta Sala, Andrea Cipriano, Chia-Lin Wei, Vittorio Sebastiano, Chi Song, Nancy R Zhang, and Kin Fai Au
Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, and Xiao-Nan Li
Prevalence of, Edison Liu, Margaret Antonio, Tracy Nance, and Francesca Menghi
iRhom2 deletion protects against diabetic neuropathy by suppressing neuroinflammation., Vitoria Mattos Pereira, Isabelle Dove Wasseen, Zhaojie Zhang, Qian-Quan Sun, Vishnu Hosur, Kelly C S Roballo, and Sreejayan Nair
A Xeno-Free Protocol for Rapid Differentiation of Human iPSC-Derived Microglia from the KOLF2.1J Reference Line, Nélio A J Oliveira, Katherine R Lewkowicz, Patricia A Clow, Michael E. Ward, Mark R. Cookson, William C Skarnes, and Justin A McDonough
An ITPR1 Variant in the IP3-ITPR1 Binding Pocket Associated With a Clinical Phenotype of Athetoid Cerebral Palsy., Thania Ordaz, Jagadish Chandrabose Sundaramurthi, Adam S Arterbery, Anita M Bagley, Michael A Gargano, Jeremy P Bauer, Daniel Danis, Philip Giampietro, Ellen Raney, Lauren Rekerle, Mallory Shingle, Jon R Davids, and Peter N Robinson
Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits in, Mohamed Ouardouz, Amanda E Hernan, J Matthew Mahoney, and Rodney C Scott
Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors., Seongyeol Park, Kijong Yi, Jieun Lee, Myung Jin Yang, Joo-Hye Song, Joonoh Lim, Taewoo Kim, Seokhwi Kim, Su Yeon Kim, Hyung-Don Kim, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Hansol Park, Jake June-Koo Lee, Yohan An, Jeonghwan Youk, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Eui-Cheol Shin, Tae Min Kim, Won Do Heo, Charles Lee, Gou Young Koh, Sung-Yup Cho, Young Seok Ju, and Young Tae Kim
Clustering of Large Human Protein Sequences Using Spark Based Hierarchical Clustering Approach, Subhadip Paul, Utsho Banerjee, Kaustav Sengupta, Moutushi Singh, and Soumyendu Sekhar Bandyopadhyay
OmNI: a modular open-source framework for interactive multi-omics data integration and visualization., Grace Potter, Jacob A Beierle, Camron Bryant, Sadhna Phanse, Carl White, Andrew Emili, and Indranil Paul
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice., G V Prateek, Zhenghao Chen, Kevin Wright, Andrea Di Francesco, Vladimir Jojic, Gary Churchill, and Anil Raj
NRN1 as a therapeutic target for Alzheimer's disease., Derian A Pugh, Gregory Cary, Kelsey M Greathouse, Lauren C Nassour-Caswell, Emma L Hobby, Nicholas T Seyfried, and Jeremy H Herskowitz
GA4GH phenopacket-driven characterization of genotype-phenotype correlations in Mendelian disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A de Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, and Peter N Robinson
The RSNA Lumbar Degenerative Imaging Spine Classification (LumbarDISC) Dataset., Tyler J Richards, Adam E Flanders, Errol Colak, Luciano M Prevedello, Robyn L Ball, Felipe Kitamura, John Mongan, Maryam Vazirabad, Hui-Ming Lin, Anne Kendell, Thanat Kanthawang, Salita Angkurawaranon, Emre Altinmakas, Hakan Dogan, Paulo Eduardo de Aguiar Kuriki, Arjuna Somasundaram, Christopher Rushton, Deniz Bulja, Naida Spahović, Jennifer Sommer, Sirui Jiang, Eduardo Moreno Júdice de Mattos Farina, Eduardo Caminha Nunes, Michael Brassil, Megan McNamara, Johanna Ortiz, Jacob Peoples, Vinson L Uytana, Anthony Kam, Venkata N S Dola, Daniel Murphy, David Vu, Arsany Hakim, Jason F Talbott, Dataset Contributor Group, Dataset Annotator Group, and Competition Data Notebook and Curation Group
Tet2 modulates ER stress responses related to β-cell death and autoimmunity in diabetes., Jinxiu Rui, Madhav Kothari, Romy Kursawe, Mahsa Nouri Barkestani, Romi Genosar, Pamela Clark, Michael L. Stitzel, and Kevan C Herold
An inflammatory and quiescent HSC subpopulation expands with age in humans., Ksenia R Safina, Basit Salik, Dylan Kotliar, Michelle Curtis, Jonathan D Good, Chen Weng, Shawn David, Soumya Raychaudhuri, Antonia Kreso, Jennifer J. Trowbridge, Vijay G Sankaran, and Peter van Galen
Overcoming EGFR-Mediated Dendritic Cell Dysfunction to Enhance Anti-tumor Immunity in EGFR-Mutant NSCLC by Precisely Targeting CD73 With pH-responsive Nanocarriers., Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, and Yanguo Liu
NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys., Satoshi Shimada, Chun Yang, Brian Hoffmann, Timothy M Stearns, Theresa Kurth, Mingyu Liang, Ranjan K Dash, and Allen W Cowley
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells., Emily R Siniscalco, Courtney Fisher, Meng-Ping Lu, Jessica D S Grassmann, Corinne D Mack, Roukaya Yaakoubi, Danielle Jacobsen, Qian Chen, Donguk Lee, Priya Rajamanimuthu, Tregony Simoneau, Kahn Preece, Paul Gray, Satoshi Okada, Bertrand Boisson, Basak Kayaoglu, Jeffrey Danielson, Alexandra F Freeman, Jean-Laurent Casanova, Talal A Chatila, Helen C Su, Cindy S Ma, Adam Williams, Stephanie C Eisenbarth, and Uthaman Gowthaman
The mouse Gene Expression Database (GXD): 2026 update., Constance M. Smith, Terry F. Hayamizu, Jacqueline H. Finger, Ingeborg J. McCright, Jingxia Xu, Jeff Campbell, Lori E. Corbani, Jake Emerson, Pete J. Frost, Hongping Liang, Joel E Richardson, Richard M. Baldarelli, and Martin Ringwald
End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin., Jessica M Snyder, David E Harrison, Ron Korstanje, Brett Ginsburg, Peter C. Reifsnyder, James Nelson, Scott Leiser, Catherine Kaczorowski, Denise M Imai, Adam B Salmon, Randy Strong, Warren Ladiges, and Richard A Miller
Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy., Kristen Springer, Heun Soh, Raquel Paz Zavala, Nissi Varghese, Cathleen Lutz, Aamir Zuberi, Alexander C Jackson, and Anastasios V Tzingounis
Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation., Whitney Stuard Sambhariya, Catherine Bowes Rickman, Patricia A D'Amore, Giulia Corradetti, Gregory S Hageman, Gareth R Howell, Olivia J Marola, Hemali Phatnani, Nancy J Philp, Debasish Sinha, Christopher B Toomey, Faith Stone, Charles Eberhart, and James T Handa
A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care., Arti Taggar, Amanda Ulrich, Yuliana Tan, Danielle E Luciano, Melinda Sanders, Elise T Courtois, and Claudio Benadiva
Development of an AAV-based gene therapy for the ocular phenotype of Friedreich's ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, and Shannon E Boye
Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach., Deependra K Thapa, Wasiuddin Najam, Erik S Parker, Xi Rita Wang, Daniel L Smith, Ufuk Beyaztas, James F Nelson, Steven N Austad, Gary Churchill, and David B Allison
A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants., Asa Thibodeau, Asuncion Mejias, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Giray N Eryilmaz, Steven Z Josefowicz, Bart Jones, Marie Wehenkel, Silke Paust, Virginia Pascual, Jacques Banchereau, Octavio Ramilo, and Duygu Ucar
Genetic counselors' perspectives and experiences with workplace genetic testing: Results of a national survey., Alexandra Truhlar, Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Katherine Hendy, W Gregory Feero, Kerry Ryan, Alyx Vogle, Sarah McCain, Rebecca A Ferber, Jill Furnival, Charles Lee, J Scott Roberts, Wendy R Uhlmann, Kunal Sanghavi, and the INSIGHT @ Work Consortium
Educational efficacy of training videos and simulators for teaching basic mouse experimental skills to novice veterinary students., Atsushi Tsukamoto, Thum Su Zan, Makie Nitta, Hiromitsu Yoshida, Hirotaka Katahira, Yoshiharu Fujita, Satoshi Takagi, and Shinichiro Nakamura
Prevention of transgene silencing during human pluripotent stem cell differentiation., Takeshi Uenaka, Alan Napole, Aninda Dibya Saha, Duo Sun, Angelina Singavarapu, Elizabeth Calzada, Jiahui Chen, Lena Erlebach, Amanda McQuade, Daniel M Ramos, Alessandra Rigamonti, Lisa Salazar, Avi J Samelson, Kamilla Sedov, Natalie J Welsh, Katleen Wild, Qianxin Wu, Ernest Arenas, Andrew R Bassett, Martin Kampmann, Deborah Kronenberg-Versteeg, Florian T Merkle, Birgitt Schüle, Leslie M Thompson, William C Skarnes, Michael E Ward, and Marius Wernig
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function., Taja Vatovec, Anna-Lena Neehus, Katherine J L Jackson, Danielle T Avery, Ivan Bagarić, Lucia Erazo, Carlos A Arango-Franco, Masato Ogishi, Syed F Ahmed, Axel Cederholm, Amanda J Russell, Erika Della Mina, Dena Al-Rifai, Rowena Bull, Lori Buetow, Steicy Sobrino, Allison Zhang, Lara Wahlster, Marine Michelet, Nima Parvaneh, Jessica Peel, Federica Barzaghi, Davide Leardini, Quentin Philippot, Francesco Saettini, Jacques Dutrieux, Benedicte de Muylder, Francesca Vendemini, Francesco Baccelli, Albert Catala, Eleonora Gambineri, Marinella Veltroni, Vignesh Pandiarajan, Yurena Aguilar, Filomeen Haerynck, Michael Elliott, Stuart Turville, Fabienne Brillot, Taushif Khan, Filippo Consonni, Laureline Berteloot, William A Sewell, Geetha Rao, Laetitia Largeaud, Francesca Conti, Cecile Roullion, Cécile Masson, Francesco Pegoraro, Tianyi Ye, Samantha Joubran, Emily Villalpando, Boris Bessot, Yoann Seeleuthner, Tom Le Voyer, Jérémie Rosain, Hailun Li, Zarah Janda, Edoardo Muratore, Camille Soudée, Eric Delabesse, Claire Goulvestre, Mohammad Shahrooei, Anne Puel, Isabelle André, Christine Bole-Feysot, Laurent Abel, Miriam Erlacher, Vivien Béziat, Chantal Lagresle-Peyrou, Remi Cheynier, Emmanuelle Six, Nico Marr, Marlène Pasquet, Laia Alsina, Christopher C Goodnow, Nils Landegren, Alessandro Aiuti, Peng Zhang, Riccardo Masetti, Danny T Huang, Cindy S Ma, Jean-Laurent Casanova, Vijay G Sankaran, Jacinta Bustamante, Stuart G Tangye, and Jonathan Bohlen
Sex-specific evolutionary programs shape recombination rate evolution in house mice., Lydia K Wooldridge, Micah Pietraho, Peyton DiSiena, Sam Littman, Benjamin Clauss, and Beth L Dumont
Genotype-Environment-Driven Dysbiosis in the Skin Microbiome of Ichthyosis., Wei Zhou, Nan G Ring, Ryan Caldwell, Leonard M Milstone, and Julia Oh
IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors., Iowis Zhu, Julian Chien, Gabriel E Rech, Kanish Mirchia, Sixuan Pan, Kaeli Miller, Joanna Pak, Rosanna Wustrack, Varun Monga, Steve E Braunstein, Mark D Adams, Line Jacques, Melike Pekmezci, S John Liu, and Harish N Vasudevan
Submissions from 2025
An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health., Mark S Scher, Harris Eyre, Steven Donn, James M Roberts, Michael E Msall, Carolyn M Salafia, Richard Towbin, Peter N Robinson, Ken Loparo, Michael Berk, Elena Moro, Valerie Smith, Susan Ludington, Nadia Badawi, Rod W Hunt, Alistair Gunn, Harvey B Sarnat, Kirthana Kunikullaya, and Betsy Pilon