Document Type
Article
Publication Date
8-1-2026
Original Citation
Iruela-Arispe M,
Hinman J,
Yang A,
Dabertrand F,
Lee J,
Howell G,
.
A collaborative framework for uncovering molecular and cellular drivers of VCID: Foundations for future interventions in dementia. Alzheimers Dement. 2026 Aug;22(8):e71701
Keywords
JMG, Humans, Animals, Dementia, Dementia, Vascular, Cognitive Dysfunction
JAX Source
Alzheimers Dement. 2026 Aug;22(8):e71701
ISSN
1552-5279
PMID
42581297
DOI
https://doi.org/10.1002/alz.71701
Grant
JAX/Emory/Columbia/Rush MINT-VCID CWOW, Grant/Award Number: NS139948
Abstract
Vascular-related factors are now considered major contributors to most forms of dementia, including Alzheimer's disease. However, the degree to which vascular deficits contribute to risk, onset, and progression of cognitive impairment and dementia has only recently been appreciated. Our understanding of the mechanisms by which vascular deficits drive cognitive decline in dementia is still limited. Further, the testing of therapeutic approaches to prevent vascular deficits to treat dementia are few. These factors motivated the establishment of the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center Without Walls (CWOW) network, comprising institutes across the United States. We describe the current gaps and opportunities, and how, in collaboration with other relevant groups, the VCID CWOW network is aiming to tackle the major unmet need of developing improved therapeutic approaches targeting vascular deficits to treat dementia.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.