Submissions from 2026
Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma., Nourhan Abdelfattah, Sivaraman Natarajan, Han Nhat Tran, Thomas Wong, Maryam Faisal, Jose Maldonado, Rachael McMinimy, Hannah Borland, Shu-Hsia Chen, Hong Zhao, Matthew Vasquez, Freddys F Rodriguez, Carston R Wagner, Fernando Camargo, James Olson, Joshy George, and Kyuson Yun
Funding FAIRly: A New Model for Biomedical Research., Anupam Agarwal, Kurt Marek, Nancy C Andrews, Diego R Vazquez, James Incalcaterra, Ming Lei, Howard Fox, Penny Gordon-Larsen, Jennifer K Lodge, Nick Wigginton, Kelvin Droegemeier, and The Subject Matter Expert Team of the Joint Associations Group
IL1A enhances TNF-induced retinal ganglion cell death., Katherine M Andersh, Michael MacLean, Gareth R Howell, and Richard T Libby
IL1A enhances TNF-induced retinal ganglion cell death., Katherine M Andersh, Michael MacLean, Gareth R Howell, and Richard T Libby
Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory., Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia J Marola, Christopher M Norris, Alaina M Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth R Howell, and Cheryl L Wellington
Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory., Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia J Marola, Christopher M Norris, Alaina M Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth R Howell, and Cheryl L Wellington
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia., Alexander Arnuk, Cuijuan Han, Abimbola Eunice Lawal, Bofei Wang, Sadik Karma, Zhiping Zhang, Mhd Yousuf Yassouf, Sakthi Harini Rajendran, Harshpreet Chandok, Madeline L Eller, Sogand Sajedi, Meryl McKenna, Eve Herman, Louisa Hagen, Bettina Nadorp, Zengshuo Mo, Hector Orellana, Aristotelis Tsirigos, Pedro Miura, Hussein A Abbas, Iannis Aifantis, and Eric Wang
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia., Alexander Arnuk, Cuijuan Han, Abimbola Eunice Lawal, Bofei Wang, Sadik Karma, Zhiping Zhang, Mhd Yousuf Yassouf, Sakthi Harini Rajendran, Harshpreet Chandok, Madeline L Eller, Sogand Sajedi, Meryl McKenna, Eve Herman, Louisa Hagen, Bettina Nadorp, Zengshuo Mo, Hector Orellana, Aristotelis Tsirigos, Pedro Miura, Hussein A Abbas, Iannis Aifantis, and Eric Wang
Roads and detours for CAR T cell therapy in autoimmune diseases., Jérôme Avouac, Adi Barzel, Delma Caiati, Randall S Davis, Stephen Gottschalk, Ricardo Grieshaber-Bouyer, Xuming Mao, Eline T Luning Prak, Marko Radic, Marc Scherlinger, Yatin Suneja, Aimee Talleur, Amber L Thacker, and Derya Unutmaz
Roads and detours for CAR T cell therapy in autoimmune diseases., Jérôme Avouac, Adi Barzel, Delma Caiati, Randall S Davis, Stephen Gottschalk, Ricardo Grieshaber-Bouyer, Xuming Mao, Eline T Luning Prak, Marko Radic, Marc Scherlinger, Yatin Suneja, Aimee Talleur, Amber L Thacker, and Derya Unutmaz
The DO-KB knowledgebase 2026 update: expanding programmatic and language access., J Allen Baron, Claudia M Sánchez-Beato Johnson, Michael A Schor, Dustin Olley, Lance Nickel, Victor Felix, Susan M. Bello, Carol Greene, Richard Lichenstein, Katharine Bisordi, Rima Koka, Cynthia Bearer, Regina Macatangay, Nischal Ada, Kaitlin Ballenger, Emily Bliss, Lauren Colliver, Grace Dobbins, Harrison Heitzig, Shannan Dixon, Patrick Semesky, Jennifer Garth, Matthew Fairchild, Peter Gaskin, Sarina Zahid, Rachel Castillo, Sarah Edwards, Astrid Widjaja, Yamei Usui, Erin Lynch, Melissa Clarkson, Todd Detwiler, and Lynn M Schriml
Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction., Laura Blanco-Berdugo, Alexis Garretson, and Beth L Dumont
Views and experiences regarding workplace genetic testing: findings from a national survey of U.S. employees., Drew Blasco, Sarah McCain, Subhamoy Pal, Wendy R Uhlmann, Rebecca Ferber, Kunal Sanghavi, Elizabeth Charnysh, Anya E R Prince, Charles Lee, J Scott Roberts, and INSIGHT @ Work Consortium
Views and experiences regarding workplace genetic testing: findings from a national survey of U.S. employees., Drew Blasco, Sarah McCain, Subhamoy Pal, Wendy R Uhlmann, Rebecca Ferber, Kunal Sanghavi, Elizabeth Charnysh, Anya E R Prince, Charles Lee, J Scott Roberts, and the INSIGHT @ Work Consortium
Inhibition of Moesin and CD44 in stem cell-derived neurons affects the pathological genetic signature associated with Alzheimer's disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, and TREAT-AD Consortium
From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood., Lauren G Brown, Xiaofu Wei, Laura A Milton, M Yunos Alizai, James W MacDonald, Theo K Bammler, Yuting Zeng, Ingrid Robertson, Karen N Adams, Yi-Chin Toh, Damien Chaussabel, Erwin Berthier, Amanda J Haack, and Ashleigh B Theberge
Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study, Daniel R Carrizosa, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Deepti Behl, Bamidele Adesunloye, Evan Pisick, Kathleen W Beekman, Efrat Dotan, Mehmet Akce, Olatunji B Alese, Vaibhav Sahai, Kelsey A Klute, Jeanny B Aragon-Ching, Kathrine A Cooper, Ramya Thota, Funda Meric-Bernstam, Peter J Hosein, Erika C Maestas, Justin T Moyers, Steven Powell, Song Zhao, Evthokia Hobbs, Jens Rueter, Davendra P S Sohal, Mark A Taylor, Dominique C Hinshaw, Abigail Gregory, Gina N Grantham, Susan Halabi, and Richard L Schilsky
Beyond the streetlight: a TREAT-AD perspective on where to find new Alzheimer's targets., Gregory Cary, Jesse C Wiley, Gregory W. Carter, and Allan I Levey
Beyond the streetlight: a TREAT-AD perspective on where to find new Alzheimer's targets., Gregory Cary, Jesse C Wiley, Gregory W. Carter, and Allan I Levey
Multiscale metabolic covariance networks uncover stage-specific biomarker signatures across the Alzheimer's disease continuum., Juan Antonio K Chong Chie, Scott A Persohn, Ravi S Pandey, Olivia R Simcox, Gregory W. Carter, Paul Salama, Paul R Territo, and the Alzheimer’s Disease Neuroimaging Initiative
JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse., Anshul Choudhary, Brian Q Geuther, Thomas J. Sproule, Glen L Beane, Vivek Kohar, Jarek Trapszo, and Vivek Kumar
JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse., Anshul Choudhary, Brian Q Geuther, Thomas J. Sproule, Glen L Beane, Vivek Kohar, Jarek Trapszo, and Vivek Kumar
Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, and Elena Gonzalo-Gil
Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, and Elena Gonzalo-Gil
Can angiotensin II affect the inflammatory response of human dental pulp cells in vitro?, Bella Luna Colombini-Ishikiriama, Thiago José Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Sandra Helena Penha Oliveira, Vanessa Soares Lara, Andrew S Greene, and Carlos Ferreira Dos Santos
Metallothionein 1 mediates growth and survival of Dnmt3a;Npm1-mutant acute myeloid leukemia, Patricia A Colom Díaz, Jayna J Mistry, Kira Young, Chih-Hsing Chou, Nathan Boyer, Ross L Levine, Nathan Salomonis, H Leighton Grimes, and Jennifer J. Trowbridge
Legislating infrastructure: a state-level model to accelerate endometriosis research and women's health equity., E T Courtois, L Roy, Jasmina Uvalic, K Mullaj, D Lockshire, and D E Luciano
Conditional Stat2 Knockout Mice as a Platform for Modeling Human Diseases., Tess Cremers, Nataliya Miz, Alexandra Afanassiev, Ling Yang, Kevin P Kotredes, and Ana M Gamero
In-depth human phenotype ontology curation boosts prioritization performance for Netherton syndrome (SPINK5-syndromic epidermal differentiation disorder)., Edwin Cuperus, Suzanne G M A Pasmans, Henry L Han, Adam S Arterbery, Daniel Danis, Michel van Geel, Cristina Has, Lisa Weibel, Katariina Hannula-Jouppi, Christine Bodemer, Alain Hovnanian, Peter N Robinson, and Mariëlle E van Gijn
Functional equivalence of γ- and x-ray irradiation for long-term peripheral blood chimerism and acute myeloid leukemia transplant outcomes in mice., Shawn David, Griffin J Nye, Elizabeth Eudy, Ewelina Bolcun-Filas, Jennifer J. Trowbridge, and Kira Young
Misregulated alternative splicing in endometriosis: a role for aberrant mRNA variants in endometriotic cell growth., Venkata Naga Goutham Davuluri, Michelle Dias, Roxanna Llinas, Neha Kamath, Pooja Popli, Shannon M Hawkins, Chandrakant Tayade, Elise T Courtois, Hari Krishna Yalamanchili, and Ramakrishna Kommagani
Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment., Alex R DeCasien, Jacob E Aronoff, Elizabeth K Mallott, Sahana Kuthyar, Sriram Chitta, Brian T Layden, Maria L Savo Sardaro, Stanton Gray, Lawrence E Williams, Emma R Liechty, Hyo M Lee, Won Lee, James P Curley, Christopher W Kuzawa, and Katherine R Amato
African Domestic Poultry Genetic Resources, Diversity, and Unique Features, Tadelle Dessie, Christian K. Tiambo, Liveness J. Banda, Raman Akinyanju Lawal, Sheila C. Ommeh, Timothy Gondwe, Esatu Wondmeneh, Matthew A. Adeleke, and Olivier Hanotte
Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder., Brianna L DiSanza, Giulia S Porcari, Livia Sertori Finoti, Leonardo Ramos-Rodriguez, Devin M Burris, Justin A McDonough, Gang Ning, Grace Fagan, Guy T Helman, Erin Weiss, Ryan J Taft, Amy Pizzino, Matthew T Whitehead, Amy Waldman, Cas Simons, Xilma Ortiz-Gonzalez, William C Skarnes, Adeline Vanderver, Elizabeth J Bhoj, and Rebecca C Ahrens-Nicklas
Building a genomics-capable cancer workforce: a competency-based framework for education and training in precision oncology., Amanda Drury, Yosr Hamdi, Nicola Mulder, Jens Rueter, Lindsey Kelley, Kathleen Blazer, Raffaella Casolino, and Stacy W Gray
Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape., Giovanna L Durante, Anna L. Tyler, Rod C Scott, Amanda E Hernan, and J Matthew Mahoney
Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape., Giovanna L Durante, Anna L. Tyler, Rod C Scott, Amanda E Hernan, and J Matthew Mahoney
Multiple Mechanisms Contribute to Robust Type 1 Diabetes Protection in Nfkbid- Overexpressing NOD Mice., Jennifer R Dwyer, Jeremy Racine, Harold D Chapman, Amy Bell, Anna Quinlan, Grace Stafford, and David V. Serreze
Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, and Duygu Ucar
Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, and Duygu Ucar
Worldwide Innovative Network Consortium: Building a Common Global Cancer Database., Farhood Farahnak, Wafik S El-Deiry, Yves A Lussier, Razelle Kurzrock, Shai Magidi, Catherine Bresson, Shirin A Enger, Jia Liu, Jair Bar, Jeremy L Warner, Tobias Meissner, Eitan Rubin, Jens Rueter, Himabindu Gaddipati, Mandar Kulkarni, Zhen Chen, Sewanti Limaye, Rachel Elsey, Brenda M Rubenstein, Anthony M Joshua, Humaid O Al-Shamsi, Khaled M Musallam, Fanny Wunder, Jacques Raynaud, Guy Berchem, Manon Gantenbein, Amal Al Omari, Said Dermime, Hikmat Abdel-Razeq, Pierre Saintigny, Andrés Cervantes, Roger R Reddel, Adel T Aref, Juan Martin-Liberal, Conxi Lázaro, David Cordero Romera, Marina Sekacheva, Raanan Berger, C S Pramesh, Ioana Berindan-Neagoe, Eugenia Girda, Alejandro Piris-Gimenez, Carol J Farhangfar, Mohammed E Salem, Rodrigo Dienstmann, Ramon Salazar, Naftali Z Frankel, Zachary Batist, Yuri Quintana, and Gerald Batist
Improving rigor and reproducibility through implementation of the ISSCR standards for human stem cell use in research., Yvonne Fischer, Jack Mosher, Ivana Barbaric, Claudia Spits, and Martin Pera
Improving rigor and reproducibility through implementation of the ISSCR standards for human stem cell use in research., Yvonne Fischer, Jack Mosher, Ivana Barbaric, Claudia Spits, and Martin Pera
New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity., Carrie A Flynn, Rebecca I Colón-Ríos, Andrew Harmez, William F Flynn, and Barbara I Kazmierczak
New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity., Carrie A Flynn, Rebecca I Colón-Ríos, Andrew Harmez, William F Flynn, and Barbara I Kazmierczak
Prediction of outcome from spatial Protein profiling of triple-negative breast cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, and Jeffrey Chuang
Prediction of outcome from spatial Protein profiling of triple-negative breast cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, and Jeffrey Chuang
Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts in mouse embryonic stem cells., Haley J Fortin, Anna Z Struba, Arad Bustan, and Christopher L. Baker
PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function., Kayla Frank, Himani Sharma, Efthymios Motakis, Nooshin Nourbakhsh, Shawn Abeynaike, Tridu R Huynh, Cheryl A Jones, Scott K Johnson, S Mark Tompkins, and Silke Paust
B cells enable autoreactive T cells to avoid suppression., Matthew Funsten, Renee de Pooter, Vineeth Varanasi, Michael Burrows, Katharine Block, Andrey Kuznetsov, David V. Serreze, Haochu Huang, and Alexander Chervonsky
Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis, Hussein Ghamlouch, Michaël Degaud, Veronique Della-Valle, Alexandre Eeckhoutte, Marine Armand, Amina Joudat, Camille Decaudin, Pilar M Dominguez, Wojciech Rosikiewicz, Patrycja Pawlikowska, Walaa Darwiche, Enguerran Mouly, Sheng Li, Ari M Melnick, Said Aoufouchi, and Olivier A Bernard
Mapping the genetic landscape across 14 psychiatric disorders., Andrew D Grotzinger, Josefin Werme, Wouter J Peyrot, Oleksandr Frei, Christiaan de Leeuw, Lucy K Bicks, Qiuyu Guo, Michael P Margolis, Brandon J Coombes, Anthony Batzler, Vanessa Pazdernik, Joanna M Biernacka, Ole A Andreassen, Verneri Anttila, Anders D Børglum, Gerome Breen, Na Cai, Ditte Demontis, Howard J Edenberg, Stephen V Faraone, Barbara Franke, Michael J Gandal, Joel Gelernter, Alexander S Hatoum, John M Hettema, Emma C Johnson, Katherine G Jonas, James A Knowles, Karestan C Koenen, Adam X Maihofer, Travis T Mallard, Manuel Mattheisen, Karen S Mitchell, Benjamin M Neale, Caroline M Nievergelt, John I Nurnberger, Kevin S O'Connell, Roseann E Peterson, Elise B Robinson, Sandra S Sanchez-Roige, Susan L Santangelo, Jeremiah M Scharf, Hreinn Stefansson, Kari Stefansson, Murray B Stein, Nora I Strom, Laura M Thornton, Elliot M Tucker-Drob, Brad Verhulst, Irwin D Waldman, G Bragi Walters, Naomi R Wray, Dongmei Yu, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nicotine Dependence GenOmics (INDIGO) Consortium, Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Phil H Lee, Kenneth S Kendler, and Jordan W Smoller
Ageing promotes microglial accumulation of slow-degrading synaptic proteins., Ian H Guldner, Viktoria P Wagner, Patricia Moran-Losada, Sophia M Shi, Sophia W Golub, Johannes F Hevler, Kelly Chen, Barbara T Meese, Ali Ghoochani, Ernst Pulido, Hamilton Se-Hwee Oh, Yann Le Guen, Nannan Lu, Pui Shuen Wong, Ning-Sum To, Dylan Garceau, Zimin Guo, Jian Luo, Carolyn R Bertozzi, Emma Lundberg, Monther Abu-Remaileh, Michael Sasner, Andreas Keller, Andrew C Yang, Tom H Cheung, and Tony Wyss-Coray
Ageing promotes microglial accumulation of slow-degrading synaptic proteins., Ian H Guldner, Viktoria P Wagner, Patricia Moran-Losada, Sophia M Shi, Sophia W Golub, Johannes F Hevler, Kelly Chen, Barbara T Meese, Ali Ghoochani, Ernst Pulido, Hamilton Se-Hwee Oh, Yann Le Guen, Nannan Lu, Pui Shuen Wong, Ning-Sum To, Dylan Garceau, Zimin Guo, Jian Luo, Carolyn R Bertozzi, Emma Lundberg, Monther Abu-Remaileh, Michael Sasner, Andreas Keller, Andrew C Yang, Tom H Cheung, and Tony Wyss-Coray
cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice., Suman Gupta, James Matsunaga, Bridget Ratitong, Andrew Manion, Sana Ismaeel, Diogo G Valadares, A Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj, Jenifer Coburn, Andrea J Wolf, Meghan A Morrissey, Suzanne L Cassel, David A Haake, and Fayyaz S Sutterwala
miRNA checking meiosis., Mary Ann Handel
miRNA checking meiosis., Mary Ann Handel
A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex., Camille M Hanes, David M Steffen, George Murray, Robert W. Burgess, Joshua A Weiner, and Andrew M Garrett
A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex., Camille M Hanes, David M Steffen, George Murray, Robert W. Burgess, Joshua A Weiner, and Andrew M Garrett
A dual role for GLI3 signaling in neural crest development., Simon J Y Han, Vinit Adani, Edward Farrow, Bhaval Parmar, Ching-Fang Chang, Kim Cochran, Ronald R Horne, Paige J K Ramkissoon, Ezekiel Esteban, Kelsey H Elliott, Kevin A Peterson, Brian Gebelein, Martín I García-Castro, and Samantha A Brugmann
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality in an MECP2 duplication mouse model., Vignesh N Hariharan, Ashley Summers, Amy E Clipperton-Allen, Jillian Caiazzi, Samuel R Hildebrand, Daniel O' Reilly, Qi Tang, Zachary Kennedy, Dimas Echeverria, Nicholas McHugh, David Cooper, Jacquelyn Sousa, Chantal Ferguson, Hassan H Fakih, Laurent P. Bogdanik, Monica Coenraads, and Anastasia Khvorova
Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury., Zachary M Harris, Asawari Korde, Johad Khoury, Edward P Manning, Gail Stanley, Yosep Shin, Kennedy Mitchell, Alexa von der Schulenburg, Ying Sun, Buqu Hu, Hyeon Jun Shin, John Joerns, Brian Clark, Lindsey Placek, Derya Unutmaz, Aigul Moldobaeva, Lokesh Sharma, Maor Sauler, Govindarajan Rajagopalan, Xuchen Zhang, He Wang, Mahboobe Ghaedi, Min-Jong Kang, and Jonathan L Koff
A complete genome for the common marmoset., Prajna Hebbar, Tamara Potapova, Hailey Loucks, Karina Ray, Murillo F Rodrigues, Fedor Ryabov, Joanna Malukiewicz, DongAhn Yoo, Leonardo Gomes de Lima, Annat Haber, Sonal Kumar, Swati Banerjee, Matthew Borchers, Gage H Garcia, Joshua Gardner, Stephanie Hachem, Harrison D Heath, Seung Kwon Ha, Mira Mastoras, Brandy McNulty, Julian Menendez, Katherine M Munson, Karol Pal, JungEun Park, Simon Plösch, Christian Roos, William E Seligmann, Valery Shepelev, Catrina Spruce, Ivo Violich, Lutz Walter, Kateryna D Makova, Amantha Thathiah, Stacey J Sukoff Rizzo, Afonso C Silva, Gregory W. Carter, Karen H Miga, Evan E Eichler, Donald F Conrad, Jennifer L Gerton, Ivan A Alexandrov, and Benedict Paten
High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape., Mohab Helmy, Jin U Li, Xinyu F Yan, Rachel K Meade, Elizabeth Anderson, Patrick B Chen, Anne M Czechanski, Tomás Di Domenico, Jonathan Flint, Erik Garrison, Marco T P Gontijo, Andrea Guarracino, Leanne Haggerty, Edith Heard, Kerstin Howe, Narendra Meena, Fergal J Martin, Eric A Miska, Isabell Rall, Navin B Ramakrishna, Alexandra Sapetschnig, Swati Sinha, Diandian Sun, Francesca F Tricomi, Runjia Qu, Jonathan M D Wood, Tianzhen Wu, Dian J Zhou, Laura G Reinholdt, David J Adams, Clare M Smith, Jingtao Lilue, and Thomas M Keane
High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape., Mohab Helmy, Jin U Li, Xinyu F Yan, Rachel K Meade, Elizabeth Anderson, Patrick B Chen, Anne M Czechanski, Tomás Di Domenico, Jonathan Flint, Erik Garrison, Marco T P Gontijo, Andrea Guarracino, Leanne Haggerty, Edith Heard, Kerstin Howe, Narendra Meena, Fergal J Martin, Eric A Miska, Isabell Rall, Navin B Ramakrishna, Alexandra Sapetschnig, Swati Sinha, Diandian Sun, Francesca F Tricomi, Runjia Qu, Jonathan M D Wood, Tianzhen Wu, Dian J Zhou, Laura G Reinholdt, David J Adams, Clare M Smith, Jingtao Lilue, and Thomas M Keane
TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi van Hijfte, Rania Head, Iris de Heer, Marta Padovan, Maurice de Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J van den Bent, Pieter Wesseling, and Pim J French
TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas., Youri Hoogstrate, Santoesha A Ghisai, Levi van Hijfte, Rania Head, Iris de Heer, Marta Padovan, Maurice de Wit, Wies R Vallentgoed, Angelo Dipasquale, Maarten M J Wijnenga, Bas Weenink, Rosa Luning, Sybren L N Maas, Adela Brzobohata, Michael Weller, Tobias Weiss, Maximilian J Mair, Anna S Berghoff, Adelheid Wöhrer, Albert Jeltsch, Johan A F Koekkoek, Hans M Hazelbag, Mathilde C M Kouwenhoven, Yongsoo Kim, Bart A Westerman, Bauke Ylstra, Anneke M Niers, Kevin C Johnson, Frederick S Varn, Roel G W Verhaak, Mustafa Khasraw, Martin J van den Bent, Pieter Wesseling, and Pim J French
How the microbiome shapes epigenetic trained memory in neuroinflammation: Implications for neurodegenerative diseases., Mian Horvath and Jaime Imitola
Understanding the contribution of toxicant exposures to Alzheimer's disease and related dementias., Gareth R Howell, Paul R Territo, David Aylor, and Lee E Goldstein
A collaborative framework for uncovering molecular and cellular drivers of VCID: Foundations for future interventions in dementia., M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, and The VCID Centers without Walls Network
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting., Ari Itoh-Nakadai, Minggao Liang, Michiho Shindo, Chen Bibi, Mariko Tomizawa-Murasawa, Saera Fujiki, Akiko Kaneko, Emi Kanamaru, Mari Hashimoto, Hiroshi Kajita, Yoshinari Ando, Miki Kojima, Jonathan Moody, Makoto Iwasaki, Shinsuke Takagi, Ryo Nakagawa, Saumya Agrawal, Hanae Amitani-Iijima, Kaori Sato, Yuriko Sorimachi, Nahoko Suzuki, Takehiro Fukami, Kazuharu Hanada, Satoshi Morita, Kazushige Katsura, Takehisa Matsumoto, Maiko Kobayashi, Masahiko Kato, Yasuyuki Negishi, Mikako Shirouzu, Yuho Najima, Keiyo Takubo, Chung Chau Hon, Naoyuki Uchida, Shuichi Taniguchi, Yukihide Momozawa, Piero Carninci, Leonard D. Shultz, Yoriko Saito, Michiel de Hoon, Jay W Shin, and Fumihiko Ishikawa
Beyond wrinkles., Sasan Jalili and Julia Oh
GPR156 is required in sensory hair cells for proper auditory and vestibular function., Amandine Jarysta, Brandie Morris Verdone, Elli I Hartig, Kathleen E Cullen, and Basile Tarchini
Single-nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a Phase 0/1 trial of recurrent high-grade glioma., Kevin C Johnson, An-Chi Tien, Jun Jiang, James McNamara, Yu-Wei Chang, Chelsea Montgomery, Anita DeSantis, Leonel Elena-Sanchez, Yoko Fujita, Seongho Kim, Avishay Spitzer, Paul Gabriel, William F Flynn, Elise T Courtois, Amy Hong, Jocelyn Harmon, Yoshie Umemura, Artak Tovmasyan, Jing Li, Shwetal Mehta, Roel G W Verhaak, and Nader Sanai
Extrachromosomal DNA amplifications exhibit distinct molecular characteristics and prognostic implications in gastric cancer., Seunghyun Kang, Donghyeok Seol, Jieun Lee, Chanmi Bang, Mira Yoo, Soyeon Kim, Sepil An, Hyeongjin Cho, Duyeong Hwang, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Hyung-Ho Kim, Eunhee Yi, Sanghyun Kim, Yun-Suhk Suh, and Hoon Kim
Sex-specific proteostasis and urothelial responses to senolytic therapy in the aged mouse bladder., Sumiran Kasturi, Arnold M Salazar, Cara C Hardy, Ron Korstanje, and Indira U Mysorekar
Sex-specific proteostasis and urothelial responses to senolytic therapy in the aged mouse bladder., Sumiran Kasturi, Arnold M Salazar, Cara C Hardy, Ron Korstanje, and Indira U Mysorekar
Identifying transcriptomic signatures that mediate the causal effect of genotype on Alzheimer's disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, and J Matthew Mahoney
Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, and Angelo D'Alessandro
Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, and Angelo D'Alessandro
Towards clinical translation of nanomedicines: Formulation scale-up and model systems., Owen M Kelly, Andrew R Hanna, Addison K Byrne, Jonathan A Green, Iuri Viotti Perisse, Kevin D Wells, Stephen A. Murray, Jie Xu, Y Eugene Chen, Irina A Polejaeva, Alice F Tarantal, David Issadore, and Alexandra S Piotrowski-Daspit
CXCR6+ natural killer cell immunotherapy preserves CD4+ T helper cells in humanized mice, Naushad Khan, Kayla Frank, and Silke Paust
Perspectives from the 2025 ISCBI/ISCI joint workshop on genetic stability, clonal monitoring, ethical data governance, and global inclusion in stem cell banking., Jung-Hyun Kim, Andreas Kurtz, Ivana Barbaric, Maneesha S Inamdar, Martin Pera, Nissim Benvenisty, Nika Shakiba, Rosario Isasi, Tadaaki Hanatani, and Glyn Stacey
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription., Minji Kim, Ping Wang, Patricia A Clow, Eli Chien, Xiaotao Wang, Jianhao Peng, Haoxi Chai, Xiyuan Liu, Byoungkoo Lee, Chew Yee Ngan, Olgica Milenkovic, Jeffrey Chuang, Chia-Lin Wei, Rafael Casellas, Albert Cheng, and Yijun Ruan
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription., Minji Kim, Ping Wang, Patricia A Clow, Eli Chien, Xiaotao Wang, Jianhao Peng, Haoxi Chai, Xiyuan Liu, Byoungkoo Lee, Chew Yee Ngan, Olgica Milenkovic, Jeffrey Chuang, Chia-Lin Wei, Rafael Casellas, Albert Cheng, and Yijun Ruan
Advancing gene and base editing for cardiovascular disease: overcoming barriers in delivery, precision and safety., Tae Kyeong Kim and J Travis Hinson
Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, ViLinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, and Erin C Hanlon
Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin., Vanessa A Leone, Katya Frazier, Manpreet Kaur, Evan A Chrisler, Ashley M Sidebottom, Ethan Tai, ViLinh Tran, Shuzhao Li, Eugene B Chang, Dean P Jones, Eve Van Cauter, and Erin C Hanlon
Improving gene isoform quantification with miniQuant., Haoran Li, Dingjie Wang, Qi Gao, Puwen Tan, Yunhao Wang, Xiaoyu Cai, Aifu Li, Yue Zhao, Andrew L Thurman, Seyed Amir Malekpour, Ying Zhang, Roberta Sala, Andrea Cipriano, Chia-Lin Wei, Vittorio Sebastiano, Chi Song, Nancy R Zhang, and Kin Fai Au
Improving gene isoform quantification with miniQuant., Haoran Li, Dingjie Wang, Qi Gao, Puwen Tan, Yunhao Wang, Xiaoyu Cai, Aifu Li, Yue Zhao, Andrew L Thurman, Seyed Amir Malekpour, Ying Zhang, Roberta Sala, Andrea Cipriano, Chia-Lin Wei, Vittorio Sebastiano, Chi Song, Nancy R Zhang, and Kin Fai Au
Telomere-to-telomere genome assembly and a pangenome for the rat., Kai Li, Julia L Ciosek, Sergey Koren, Adam M Phillippy, Yaming Zhu, William A Lauer, Shelise Y Brooks, Gerard G Bouffard, Brandon D Pickett, Beth L Dumont, Melissa L Smith, Theodore S Kalbfleisch, and Peter A Doris
Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, and Xiao-Nan Li
Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, and Xiao-Nan Li
Prevalence of, Edison Liu, Margaret Antonio, Tracy Nance, and Francesca Menghi
Prevalence of, Edison Liu, Margaret Antonio, Tracy Nance, and Francesca Menghi
iRhom2 deletion protects against diabetic neuropathy by suppressing neuroinflammation., Vitoria Mattos Pereira, Isabelle Dove Wasseen, Zhaojie Zhang, Qian-Quan Sun, Vishnu Hosur, Kelly C S Roballo, and Sreejayan Nair
iRhom2 deletion protects against diabetic neuropathy by suppressing neuroinflammation., Vitoria Mattos Pereira, Isabelle Dove Wasseen, Zhaojie Zhang, Qian-Quan Sun, Vishnu Hosur, Kelly C S Roballo, and Sreejayan Nair
Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis., Jayna J Mistry, Kira Young, Anna Navarro Figueredo, Gibran Edun, Alicia G Aguilar-Navarro, Patricia A Colom Díaz, Maria Telpoukhovskaia, Inés Fernández Maestre, Sheng F Cai, Katharina S Götze, Anastasia N Tikhonova, Ross L Levine, and Jennifer J. Trowbridge
Morally relevant features warranting ethical oversight in human stem cell-based embryo models., Naomi Moris, Alfonso Martinez Arias, Martin Pera, Nicolas Rivron, Karen Sermon, and Nienke de Graeff
Fusion of IgG antibodies to albumin inhibits transport across the placenta., Jeannette Nilsen, Kine M K Sand, Hana J Al-Khabbaz, Lennart Maximilian van Ligtenberg, Simone Mester, Line Mathiesen, Hanna T Noordzij, Kjell-Rune Jensen, Nils Leitzinger, Oda Ottersen, Sopisa Benjakul, Marie Leangen Herigstad, Fulgencio Ruso-Julve, Aina Karen Anthi, Anders Moen, Mari Nyquist-Andersen, Torleif Tollefsrud Gjølberg, Eirin Listau Bertelsen, Jason Cameron, Stian Foss, Gregory J. Christianson, Tilman Schlothauer, Tor Brynjar Stuge, Lisbeth E Knudsen, Inger Sandlie, Derry C. Roopenian, Maria Therese Ahlen, and Jan Terje Andersen