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Submissions from 2026

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The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias., Adrian L Oblak, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff Rizzo, Karina Leal, Paul R Territo, and Bruce T Lamb

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Rethinking ratio-based normalization towards model-based approaches in heart weight analysis., Manuela A Oestereicher, Patricia da Silva-Buttkus, Valérie Gailus-Durner, Susan Marschall, Helmut Fuchs, IMPC Consortium, Martin Hrabě de Angelis, Elida Schneltzer, and Nadine Spielmann

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A Xeno-Free Protocol for Rapid Differentiation of Human iPSC-Derived Microglia from the KOLF2.1J Reference Line, Nélio A J Oliveira, Katherine R Lewkowicz, Patricia A Clow, Michael E. Ward, Mark R. Cookson, William C Skarnes, and Justin A McDonough

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An ITPR1 Variant in the IP3-ITPR1 Binding Pocket Associated With a Clinical Phenotype of Athetoid Cerebral Palsy., Thania Ordaz, Jagadish Chandrabose Sundaramurthi, Adam S Arterbery, Anita M Bagley, Michael A Gargano, Jeremy P Bauer, Daniel Danis, Philip Giampietro, Ellen Raney, Lauren Rekerle, Mallory Shingle, Jon R Davids, and Peter N Robinson

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Auditory Stimulation Rescues Cognitive Deficit in, Mohamed Ouardouz, Amanda E Hernan, J Matthew Mahoney, and Rodney C Scott

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Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits in, Mohamed Ouardouz, Amanda E Hernan, J Matthew Mahoney, and Rodney C Scott

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Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits in, Mohamed Ouardouz, Amanda E Hernan, J Matthew Mahoney, and Rodney C Scott

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Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors., Seongyeol Park, Kijong Yi, Jieun Lee, Myung Jin Yang, Joo-Hye Song, Joonoh Lim, Taewoo Kim, Seokhwi Kim, Su Yeon Kim, Hyung-Don Kim, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Hansol Park, Jake June-Koo Lee, Yohan An, Jeonghwan Youk, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Eui-Cheol Shin, Tae Min Kim, Won Do Heo, Charles Lee, Gou Young Koh, Sung-Yup Cho, Young Seok Ju, and Young Tae Kim

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Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors., Seongyeol Park, Kijong Yi, Jieun Lee, Myung Jin Yang, Joo-Hye Song, Joonoh Lim, Taewoo Kim, Seokhwi Kim, Su Yeon Kim, Hyung-Don Kim, Yoon Ho Kim, Sae Bom Lee, Yoo Jin Jung, Hansol Park, Jake June-Koo Lee, Yohan An, Jeonghwan Youk, Kwon Joong Na, Samina Park, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Eui-Cheol Shin, Tae Min Kim, Won Do Heo, Charles Lee, Gou Young Koh, Sung-Yup Cho, Young Seok Ju, and Young Tae Kim

Clustering of Large Human Protein Sequences Using Spark Based Hierarchical Clustering Approach, Subhadip Paul, Utsho Banerjee, Kaustav Sengupta, Moutushi Singh, and Soumyendu Sekhar Bandyopadhyay

Clustering of Large Human Protein Sequences Using Spark Based Hierarchical Clustering Approach, Subhadip Paul, Utsho Banerjee, Kaustav Sengupta, Moutushi Singh, and Soumyendu Sekhar Bandyopadhyay

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Temsirolimus in Patients With Solid Tumors With, Evan Pisick, Michael Rothe, Elizabeth Garrett-Mayer, Gordan Srkalovic, John K Chan, Carmen J Calfa, Charles A Leath, Alissa S Marr, Philip J Gold, Erin K Crane, Justin T Moyers, Kathleen Yost Butler, Anu Gaba, Ramya Thota, Kathleen K Harnden, Olatunji B Alese, Angela Jain, Jens Rueter, Sarah Gill, Thomas J George, Marina Frimer, Fadi Kayali, Pam K Mangat, Dominique C Hinshaw, Abigail Gregory, Gina N Grantham, Susan Halabi, and Richard L Schilsky

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OmNI: a modular open-source framework for interactive multi-omics data integration and visualization., Grace Potter, Jacob A Beierle, Camron Bryant, Sadhna Phanse, Carl White, Andrew Emili, and Indranil Paul

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Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice., G V Prateek, Zhenghao Chen, Kevin Wright, Andrea Di Francesco, Vladimir Jojic, Gary Churchill, and Anil Raj

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Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice., G V Prateek, Zhenghao Chen, Kevin Wright, Andrea Di Francesco, Vladimir Jojic, Gary Churchill, and Anil Raj

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NRN1 as a therapeutic target for Alzheimer's disease., Derian A Pugh, Gregory Cary, Kelsey M Greathouse, Lauren C Nassour-Caswell, Emma L Hobby, Nicholas T Seyfried, and Jeremy H Herskowitz

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NRN1 as a therapeutic target for Alzheimer's disease., Derian A Pugh, Gregory Cary, Kelsey M Greathouse, Lauren C Nassour-Caswell, Emma L Hobby, Nicholas T Seyfried, and Jeremy H Herskowitz

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A cross-organ single-cell analysis of hypertension., Qiongzi Qiu, Yong Liu, Hong Xue, Rajan Pandey, Jing Liu, Lishu He, Pengyuan Liu, Bhavika Therani, Vinod Kumar, Jing Huang, Shima Sadri, Maya Guenther, Kristie Usa, Michael Grzybowski, Mark A Vanden Avond, Andrew S Greene, Allen W Cowley, Sridhar Rao, Aron M Geurts, and Mingyu Liang

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Systematic benchmarking demonstrates large language models have not reached the diagnostic accuracy of traditional rare-disease decision support tools., Justin T Reese, Leonardo Chimirri, Yasemin Bridges, Daniel Danis, J Harry Caufield, Michael A Gargano, Carlo Kroll, Andrew Schmeder, Fengchen Liu, Kyran Wissink, Julie A McMurry, Adam S L Graefe, Enock Niyonkuru, Daniel R Korn, Elena Casiraghi, Giorgio Valentini, Julius O B Jacobsen, Melissa Haendel, Damian Smedley, Christopher J Mungall, and Peter N Robinson

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GA4GH phenopacket-driven characterization of genotype-phenotype correlations in Mendelian disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A de Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, and Peter N Robinson

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The RSNA Lumbar Degenerative Imaging Spine Classification (LumbarDISC) Dataset., Tyler J Richards, Adam E Flanders, Errol Colak, Luciano M Prevedello, Robyn L Ball, Felipe Kitamura, John Mongan, Maryam Vazirabad, Hui-Ming Lin, Anne Kendell, Thanat Kanthawang, Salita Angkurawaranon, Emre Altinmakas, Hakan Dogan, Paulo Eduardo de Aguiar Kuriki, Arjuna Somasundaram, Christopher Rushton, Deniz Bulja, Naida Spahović, Jennifer Sommer, Sirui Jiang, Eduardo Moreno Júdice de Mattos Farina, Eduardo Caminha Nunes, Michael Brassil, Megan McNamara, Johanna Ortiz, Jacob Peoples, Vinson L Uytana, Anthony Kam, Venkata N S Dola, Daniel Murphy, David Vu, Arsany Hakim, Jason F Talbott, Dataset Contributor Group, Dataset Annotator Group, and Competition Data Notebook and Curation Group

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The RSNA Lumbar Degenerative Imaging Spine Classification (LumbarDISC) Dataset., Tyler J Richards, Adam E Flanders, Errol Colak, Luciano M Prevedello, Robyn L Ball, Felipe Kitamura, John Mongan, Maryam Vazirabad, Hui-Ming Lin, Anne Kendell, Thanat Kanthawang, Salita Angkurawaranon, Emre Altinmakas, Hakan Dogan, Paulo Eduardo de Aguiar Kuriki, Arjuna Somasundaram, Christopher Rushton, Deniz Bulja, Naida Spahović, Jennifer Sommer, Sirui Jiang, Eduardo Moreno Júdice de Mattos Farina, Eduardo Caminha Nunes, Michael Brassil, Megan McNamara, Johanna Ortiz, Jacob Peoples, Vinson L Uytana, Anthony Kam, Venkata N S Dola, Daniel Murphy, David Vu, Arsany Hakim, Jason F Talbott, Dataset Contributor Group, Dataset Annotator Group, and Competition Data Notebook and Curation Group

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Tet2 modulates ER stress responses related to β-cell death and autoimmunity in diabetes., Jinxiu Rui, Madhav Kothari, Romy Kursawe, Mahsa Nouri Barkestani, Romi Genosar, Pamela Clark, Michael L. Stitzel, and Kevan C Herold

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Tet2 modulates ER stress responses related to β-cell death and autoimmunity in diabetes., Jinxiu Rui, Madhav Kothari, Romy Kursawe, Mahsa Nouri Barkestani, Romi Genosar, Pamela Clark, Michael L. Stitzel, and Kevan C Herold

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An inflammatory and quiescent HSC subpopulation expands with age in humans., Ksenia R Safina, Basit Salik, Dylan Kotliar, Michelle Curtis, Jonathan D Good, Chen Weng, Shawn David, Soumya Raychaudhuri, Antonia Kreso, Jennifer J. Trowbridge, Vijay G Sankaran, and Peter van Galen

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An inflammatory and quiescent HSC subpopulation expands with age in humans., Ksenia R Safina, Basit Salik, Dylan Kotliar, Michelle Curtis, Jonathan D Good, Chen Weng, Shawn David, Soumya Raychaudhuri, Antonia Kreso, Jennifer J. Trowbridge, Vijay G Sankaran, and Peter van Galen

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Overcoming EGFR-Mediated Dendritic Cell Dysfunction to Enhance Anti-tumor Immunity in EGFR-Mutant NSCLC by Precisely Targeting CD73 With pH-responsive Nanocarriers., Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, and Yanguo Liu

NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys., Satoshi Shimada, Chun Yang, Brian Hoffmann, Timothy M Stearns, Theresa Kurth, Mingyu Liang, Ranjan K Dash, and Allen W Cowley

NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys., Satoshi Shimada, Chun Yang, Brian Hoffmann, Tim J Stodola, Theresa Kurth, Mingyu Liang, Ranjan K Dash, and Allen W Cowley

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DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells., Emily R Siniscalco, Courtney Fisher, Meng-Ping Lu, Jessica D S Grassmann, Corinne D Mack, Roukaya Yaakoubi, Danielle Jacobsen, Qian Chen, Donguk Lee, Priya Rajamanimuthu, Tregony Simoneau, Kahn Preece, Paul Gray, Satoshi Okada, Bertrand Boisson, Basak Kayaoglu, Jeffrey Danielson, Alexandra F Freeman, Jean-Laurent Casanova, Talal A Chatila, Helen C Su, Cindy S Ma, Adam Williams, Stephanie C Eisenbarth, and Uthaman Gowthaman

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The mouse Gene Expression Database (GXD): 2026 update., Constance M. Smith, Terry F. Hayamizu, Jacqueline H. Finger, Ingeborg J. McCright, Jingxia Xu, Jeff Campbell, Lori E. Corbani, Jake Emerson, Pete J. Frost, Hongping Liang, Joel E Richardson, Richard M. Baldarelli, and Martin Ringwald

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End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin., Jessica M Snyder, David E Harrison, Ron Korstanje, Brett Ginsburg, Peter C. Reifsnyder, James Nelson, Scott Leiser, Catherine Kaczorowski, Denise M Imai, Adam B Salmon, Randy Strong, Warren Ladiges, and Richard A Miller

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End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin., Jessica M Snyder, David E Harrison, Ron Korstanje, Brett Ginsburg, Peter C. Reifsnyder, James Nelson, Scott Leiser, Catherine Kaczorowski, Denise M Imai, Adam B Salmon, Randy Strong, Warren Ladiges, and Richard A Miller

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Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy., Kristen Springer, Heun Soh, Raquel Paz Zavala, Nissi Varghese, Cathleen Lutz, Aamir Zuberi, Alexander C Jackson, and Anastasios V Tzingounis

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Spoti-find: a novel, open-source void spot assay image analysis tool., Cara M. Statz, Susan Sheehan, Seamus Mawe, Nick Sebasco, Will Ricke, J Matthew Mahoney, and Ron Korstanje

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Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation., Whitney Stuard Sambhariya, Catherine Bowes Rickman, Patricia A D'Amore, Giulia Corradetti, Gregory S Hageman, Gareth R Howell, Olivia J Marola, Hemali Phatnani, Nancy J Philp, Debasish Sinha, Christopher B Toomey, Faith Stone, Charles Eberhart, and James T Handa

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Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation., Whitney Stuard Sambhariya, Catherine Bowes Rickman, Patricia A D'Amore, Giulia Corradetti, Gregory S Hageman, Gareth R Howell, Olivia J Marola, Hemali Phatnani, Nancy J Philp, Debasish Sinha, Christopher B Toomey, Faith Stone, Charles Eberhart, and James T Handa

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A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care., Arti Taggar, Amanda Ulrich, Yuliana Tan, Danielle E Luciano, Melinda Sanders, Elise T Courtois, and Claudio Benadiva

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A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care., Arti Taggar, Amanda Ulrich, Yuliana Tan, Danielle E Luciano, Melinda Sanders, Elise T Courtois, and Claudio Benadiva

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Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200, Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Yuji Nishimura, Takeshi Iwasaki, Shohei Hori, Hiroshi Kawamoto, Hiroki Kato, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, and Keiji Hirota

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Development of an AAV-based gene therapy for the ocular phenotype of Friedreich's ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, and Shannon E Boye

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Development of an AAV-based gene therapy for the ocular phenotype of Friedreich's ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, and Shannon E Boye

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Inner ear deficits complicate interpretation of depression-like behaviors in, Basile Tarchini, Ruth Anne Eatock, Katie S Kindt, Cesare Orlandi, and Kathleen E Cullen

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Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach., Deependra K Thapa, Wasiuddin Najam, Erik S Parker, Xi Rita Wang, Daniel L Smith, Ufuk Beyaztas, James F Nelson, Steven N Austad, Gary Churchill, and David B Allison

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Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach., Deependra K Thapa, Wasiuddin Najam, Erik S Parker, Xi Rita Wang, Daniel L Smith, Ufuk Beyaztas, James F Nelson, Steven N Austad, Gary Churchill, and David B Allison

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A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants., Asa Thibodeau, Asuncion Mejias, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Giray N Eryilmaz, Steven Z Josefowicz, Bart Jones, Marie Wehenkel, Silke Paust, Virginia Pascual, Jacques Banchereau, Octavio Ramilo, and Duygu Ucar

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A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants., Asa Thibodeau, Asuncion Mejias, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Giray N Eryilmaz, Steven Z Josefowicz, Bart Jones, Marie Wehenkel, Silke Paust, Virginia Pascual, Jacques Banchereau, Octavio Ramilo, and Duygu Ucar

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Multicenter Histology Image Integration and Multiscale Deep Learning Support Machine Learning-Enabled Pediatric Sarcoma Classification., Adam H Thiesen, Sergii Domanskyi, Ali Foroughi Pour, Jingyan Zhang, Todd B Sheridan, Steven Neuhauser, Alyssa Stetson, Katelyn Dannheim, Jonathan C Henriksen, Danielle B Cameron, Shawn Ahn, Hao Wu, Emily R Christison Lagay, Carol J Bult, Eleanor Y Chen, Jeffrey Chuang, and Jill C Rubinstein

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Genetic counselors' perspectives and experiences with workplace genetic testing: Results of a national survey., Alexandra Truhlar, Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Katherine Hendy, W Gregory Feero, Kerry Ryan, Alyx Vogle, Sarah McCain, Rebecca A Ferber, Jill Furnival, Charles Lee, J Scott Roberts, Wendy R Uhlmann, Kunal Sanghavi, and INSIGHT @ Work Consortium

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Genetic counselors' perspectives and experiences with workplace genetic testing: Results of a national survey., Alexandra Truhlar, Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Katherine Hendy, W Gregory Feero, Kerry Ryan, Alyx Vogle, Sarah McCain, Rebecca A Ferber, Jill Furnival, Charles Lee, J Scott Roberts, Wendy R Uhlmann, Kunal Sanghavi, and the INSIGHT @ Work Consortium

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Educational efficacy of training videos and simulators for teaching basic mouse experimental skills to novice veterinary students., Atsushi Tsukamoto, Thum Su Zan, Makie Nitta, Hiromitsu Yoshida, Hirotaka Katahira, Yoshiharu Fujita, Satoshi Takagi, and Shinichiro Nakamura

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7th International Workshop on SOX Transcription Factors., Aya Uchida

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Prevention of transgene silencing during human pluripotent stem cell differentiation., Takeshi Uenaka, Alan Napole, Aninda Dibya Saha, Duo Sun, Angelina Singavarapu, Elizabeth Calzada, Jiahui Chen, Lena Erlebach, Amanda McQuade, Daniel M Ramos, Alessandra Rigamonti, Lisa Salazar, Avi J Samelson, Kamilla Sedov, Natalie J Welsh, Katleen Wild, Qianxin Wu, Ernest Arenas, Andrew R Bassett, Martin Kampmann, Deborah Kronenberg-Versteeg, Florian T Merkle, Birgitt Schüle, Leslie M Thompson, William C Skarnes, Michael E Ward, and Marius Wernig

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Prevention of transgene silencing during human pluripotent stem cell differentiation., Takeshi Uenaka, Alan Napole, Aninda Dibya Saha, Duo Sun, Angelina Singavarapu, Elizabeth Calzada, Jiahui Chen, Lena Erlebach, Amanda McQuade, Daniel M Ramos, Alessandra Rigamonti, Lisa Salazar, Avi J Samelson, Kamilla Sedov, Natalie J Welsh, Katleen Wild, Qianxin Wu, Ernest Arenas, Andrew R Bassett, Martin Kampmann, Deborah Kronenberg-Versteeg, Florian T Merkle, Birgitt Schüle, Leslie M Thompson, William C Skarnes, Michael E Ward, and Marius Wernig

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Mondo: integrating disease terminology across communities., Nicole A Vasilevsky, Sabrina Toro, Nicolas Matentzoglu, Joseph E Flack, Kathleen R Mullen, Harshad Hegde, Sarah Gehrke, Patricia L Whetzel, Yousif Shwetar, Nomi L Harris, Mee S Ngu, Gioconda L Alyea, Megan S Kane, Paola Roncaglia, Eric Sid, Courtney L Thaxton, Valerie Wood, Roshini S Abraham, Maria Isabel Achatz, Pamela Ajuyah, Joanna S Amberger, Lawrence Babb, Jasmine Baker, James P Balhoff, Jonathan S Berg, Amol Bhalla, Xavier Bofill-De Ros, Ian R Braun, Eleanor C Broeren, Blake K Byer, Alicia B Byrne, Tiffany J Callahan, Leigh Carmody, Lauren E Chan, Amanda R Clause, Julie S Cohen, Marcello DeLuca, Natalie T Deuitch, May Flowers, Jamie Fraser, Toyofumi Fujiwara, Vanessa Gitau, Jennifer L Goldstein, Dylan Gration, Tudor Groza, Benjamin M Gyori, William Hankey, Jason A Hilton, Daniel S Himmelstein, Stephanie S Hong, Charles T Hoyt, Robert Huether, Eric Hurwitz, Julius O B Jacobsen, Atsuo Kikuchi, Sebastian Köhler, Daniel R Korn, David Lagorce, Bryan J Laraway, Jane Y Li, Adriana J Malheiro, James McLaughlin, Birgit H M Meldal, Shruthi Mohan, Sierra A T Moxon, Monica C Munoz-Torres, Tristan H Nelson, Frank W Nicholas, David Ochoa, Daniel Olson, Tudor I Oprea, Tomiko T Oskotsky, David Osumi-Sutherland, Kelley Paris, Helen E Parkinson, Zoë M Pendlington, Xiao P Peng, Amy Pizzino, Sharon E Plon, Bradford C Powell, Julie C Ratliff, Heidi L Rehm, Lyubov Remennik, Erin R Riggs, Sean Roberts, Peter N Robinson, Justyne E Ross, Kevin Schaper, Brian M Schilder, Johanna L Schmidt, Elliott W Sharp, Morgan N Similuk, Damian Smedley, Tam P Sneddon, Rachel Sparks, Ray Stefancsik, Gregory S Stupp, Shilpa Sundar, Terue Takatsuki, Imke Tammen, Kezang C Tshering, Deepak R Unni, Eloise Valasek, Adeline Vanderver, Alex H Wagner, Ryan F Webb, Danielle Welter, Doron Yaya-Stupp, Andreas Zankl, Xingmin Aaron Zhang, Julie A McMurry, Christopher G Chute, Ada Hamosh, Christopher J Mungall, and Melissa A Haendel

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Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function., Taja Vatovec, Anna-Lena Neehus, Katherine J L Jackson, Danielle T Avery, Ivan Bagarić, Lucia Erazo, Carlos A Arango-Franco, Masato Ogishi, Syed F Ahmed, Axel Cederholm, Amanda J Russell, Erika Della Mina, Dena Al-Rifai, Rowena Bull, Lori Buetow, Steicy Sobrino, Allison Zhang, Lara Wahlster, Marine Michelet, Nima Parvaneh, Jessica Peel, Federica Barzaghi, Davide Leardini, Quentin Philippot, Francesco Saettini, Jacques Dutrieux, Benedicte de Muylder, Francesca Vendemini, Francesco Baccelli, Albert Catala, Eleonora Gambineri, Marinella Veltroni, Vignesh Pandiarajan, Yurena Aguilar, Filomeen Haerynck, Michael Elliott, Stuart Turville, Fabienne Brillot, Taushif Khan, Filippo Consonni, Laureline Berteloot, William A Sewell, Geetha Rao, Laetitia Largeaud, Francesca Conti, Cecile Roullion, Cécile Masson, Francesco Pegoraro, Tianyi Ye, Samantha Joubran, Emily Villalpando, Boris Bessot, Yoann Seeleuthner, Tom Le Voyer, Jérémie Rosain, Hailun Li, Zarah Janda, Edoardo Muratore, Camille Soudée, Eric Delabesse, Claire Goulvestre, Mohammad Shahrooei, Anne Puel, Isabelle André, Christine Bole-Feysot, Laurent Abel, Miriam Erlacher, Vivien Béziat, Chantal Lagresle-Peyrou, Remi Cheynier, Emmanuelle Six, Nico Marr, Marlène Pasquet, Laia Alsina, Christopher C Goodnow, Nils Landegren, Alessandro Aiuti, Peng Zhang, Riccardo Masetti, Danny T Huang, Cindy S Ma, Jean-Laurent Casanova, Vijay G Sankaran, Jacinta Bustamante, Stuart G Tangye, and Jonathan Bohlen

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Integration of a neuronal RNAseq dataset with the draft Gryllus bimaculatus transcriptome refines gene predictions and highlights potential systematic response to injury., Felicia F Wang, Harrison P Fisher, Lisa M Ledwidge, Joel H Graber, Riley A Grindle, Jarod A Rollins, and Hadley W Horch

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NBL1 associates with renal phenotypes in mice, but partial Nbl1 reduction does not ameliorate kidney disease., Courtney Willey, Rei Bufi, Yuka Takemon, Abigail Brackett, Alicia Warren, Samantha Spellacy, Daniel M Gatti, Susan Sheehan, and Ron Korstanje

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Sex-specific evolutionary programs shape recombination rate evolution in house mice., Lydia K Wooldridge, Micah Pietraho, Peyton DiSiena, Sam Littman, Benjamin Clauss, and Beth L Dumont

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Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, and Yang Yang

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Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, and Yang Yang

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Optimizing the characterization and quantification of retinal ganglion cell somas in healthy and injured retinas using cellpose., Sarah E R Yablonski, Abigail Bishop, Sean D Lydon, Ivan Zhu, Nicole Wang, Olivia J Marola, and Richard T Libby

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Optimizing the characterization and quantification of retinal ganglion cell somas in healthy and injured retinas using cellpose., Sarah E R Yablonski, Abigail Bishop, Sean D Lydon, Ivan Zhu, Nicole Wang, Olivia J Marola, and Richard T Libby

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Editorial: Interdisciplinary innovations in CAR T-cell therapy for autoimmune and cancer treatment., Apostolos Zaravinos, Derya Unutmaz, and Marko Radic

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Editorial: Interdisciplinary innovations in CAR T-cell therapy for autoimmune and cancer treatment., Apostolos Zaravinos, Derya Unutmaz, and Marko Radic

The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis., Lei Zhang, Cuijuan Han, Man Mohan Shrestha, Jiamei Le, Wilhelm K Berger, Yiheng Huang, Reina Desrouleaux, Eric Wang, Laszlo Nagy, and Xiaoyong Yang

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Genotype-Environment-Driven Dysbiosis in the Skin Microbiome of Ichthyosis., Wei Zhou, Nan G Ring, Ryan Caldwell, Leonard M Milstone, and Julia Oh

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IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors., Iowis Zhu, Julian Chien, Gabriel E Rech, Kanish Mirchia, Sixuan Pan, Kaeli Miller, Joanna Pak, Rosanna Wustrack, Varun Monga, Steve E Braunstein, Mark D Adams, Line Jacques, Melike Pekmezci, S John Liu, and Harish N Vasudevan

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IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors., Iowis Zhu, Julian Chien, Gabriel E Rech, Kanish Mirchia, Sixuan Pan, Kaeli Miller, Joanna Pak, Rosanna Wustrack, Varun Monga, Steve E Braunstein, Mark D Adams, Line Jacques, Melike Pekmezci, S John Liu, and Harish N Vasudevan

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miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, and Michelle E Ehrlich

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Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells., Yiming Zhu, Baoshan Ding, Haimei Lv, Hui Xu, Jiamei Chen, Juan Xu, Qian Wu, Xiaoxiao Hao, Yunqi Hu, Jian Guo, Jun Chen, Chaofeng Liang, Yuzhuang Li, Jiawen Wu, Nan Cao, Jijun Zhao, Guangwen Ren, Hua Jin, Yiwen Zhang, Yiping Li, Hui Zhang, and Chunliang Xu

Submissions from 2025

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An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health., Mark S Scher, Harris Eyre, Steven Donn, James M Roberts, Michael E Msall, Carolyn M Salafia, Richard Towbin, Peter N Robinson, Ken Loparo, Michael Berk, Elena Moro, Valerie Smith, Susan Ludington, Nadia Badawi, Rod W Hunt, Alistair Gunn, Harvey B Sarnat, Kirthana Kunikullaya, and Betsy Pilon

2.34 - Fundamentals of in vivo sampling, Katarzyna Woźniczka, Miao Yu, Nikita Looby, and Anna Roszkowska

Fundamentals of In Vitro Sampling, Katarzyna Woźniczka, Miao Yu, Nikita Looby, and Anna Roszkowska