Document Type
Article
Publication Date
2-1-2026
Original Citation
Taggar A,
Ulrich A,
Tan Y,
Luciano D,
Sanders M,
Courtois E,
Benadiva C.
A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care. F S Rep. 2026;7(1):31–7.
Keywords
JGM, SS1
JAX Source
F S Rep. 2026;7(1):31–7.
ISSN
2666-3341
PMID
41694261
DOI
https://doi.org/10.1016/j.xfre.2025.11.005
Abstract
OBJECTIVE: To study the associations of B cell lymphoma 6 (BCL6) in endometrial endometriosis, and to determine a practice's experience testing BCL6 in patients with recurrent pregnancy loss/recurrent implantation failure (RPL/RIF).
DESIGN: Retrospective chart review.
SUBJECTS: Endometrial samples were collected at the time of laparoscopy from 19 reproductive-aged individuals with known stage II-IV endometriosis. Endometrium biopsies were also collected from eight healthy controls, at a single academic center.
EXPOSURE: Results using standard immunohistochemical staining for BCL6 on endometrial biopsies from October 2019 to March 2023 were obtained. For the in vitro fertilization patients with a positive BCL6 result (HSCORE
MAIN OUTCOME MEASURES: Outcomes for the embryo transfer cycle immediately after that biopsy/intervention were analyzed. Descriptive statistics with independent t-tests for continuous data, and χ
RESULTS: We found no significant upregulation of
CONCLUSION: The relationship between BCL6 and endometriosis may not be the golden solution to a single marker focus for testing, or for subsequent therapy planning among infertility patients. Clinicians should be cautious in using single marker testing for diagnosing and treating endometriosis in patients without strong additional therapeutic evidence.
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